e-Drug3D

842

cas 85622-93-1

CLASS

ANTINEOPLASTIC
ALKYLATING DNA
ALKYLATION (METHYLATION) OCCURS MAINLY AT THE O6 AND N7 POSITIONS OF GUANINE

ROUTE (list)

ORAL INTRAVENOUS

PK parameters

F 100 PERCENT
Tmax 1 HOUR
VD 26 LITER
Cl 8.8 LITER / HOUR
PPB 95 PERCENT
t1/2 1.8 HOUR

MW 194.17
NB_atoms 14
XLogP -2.08
PSA 101.461
NB_HD 2
NB_HA 8
fsp3 0.17
Lipinski(0=no;1=yes) 1

FDA
NDA 021029 (label) INN (TEMOZOLOMIDE) TEMODAR (MERCK SHARP DOHME) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 022277 (label) INN (TEMOZOLOMIDE) TEMODAR (MERCK SHARP DOHME) APPROVAL= AP YEAR= 2009
NDA 078879 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (HERITAGE) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 201742 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (SUN PHARM) APPROVAL= AP YEAR= 2014
NDA 203691 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2015
NDA 205227 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (EXTROVIS) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203898 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (EIRGEN) APPROVAL= AP YEAR= 2016
NDA 206309 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (RISING) APPROVAL= AP YEAR= 2016
NDA 206413 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (CHARTWELL) APPROVAL= AP YEAR= 2016
NDA 203490 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (ANI PHARMS) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 204639 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (CHEMI SPA) APPROVAL= AP YEAR= 2016
NDA 201528 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2017
NDA 203959 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 206750 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 207658 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (DEVA HOLDING AS) APPROVAL= AP YEAR= 2017
NDA 204159 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (APOTEX) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 213328 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (NIVAGEN PHARMS INC) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 210030 (pdf not found) INN (TEMOZOLOMIDE) TEMOZOLOMIDE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2024