e-Drug3D

779

SPARFLOXACIN

DISCONTINUED

INN
SPARFLOXACIN

cas 110871-86-8

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL AGENTS
DNA GYRASE (A BACTERIAL TOPOISOMERASE) INHIBITOR

ROUTE (list)

ORAL

ATC code

J01MA09

PK parameters

F 92 PERCENT
Tmax 4.5 HOUR
VD 253 LITER (65 KILOGRAM)
Cl 11.4 LITER / HOUR
PPB 45 PERCENT
t1/2 20 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET DNA GYRASE

Topoisomerase IV UNIPROT P0AFI2 parC

DNA gyrase UNIPROT P0AES4 gyrA

Download SDF file

5-amino-1-cyclopropyl-7-[(3S,5R)-3,5-dimethylpiperazin-1-yl]-6,8-difluoro-4-oxoquinoline-3-carboxylic acid

Formula:
C19H22F2N4O3

Calculated chemical properties:

MW 391.40
NB_atoms 28
XLogP 0.75
PSA 92.283
NB_HD 3
NB_HA 7
fsp3 0.47
Lipinski(0=no;1=yes) 1

FDA
NDA 020677 (label) INN (SPARFLOXACIN) ZAGAM (MYLAN) APPROVAL= AP YEAR= 1996 NEWMOLECULARENTITY DISCONTINUED