e-Drug3D

774

cas 155213-67-5

CLASS

ANTIINFECTIVES
ANTIVIRAL
ANTI-HIV
HIV PROTEASE INHIBITORS

ROUTE (list)

ORAL

PK parameters

Tmax 3 HOUR
Cmax 15.5 MICROMOLAR
VD 26.6 LITER (65 KILOGRAM)
Cl 8.8 LITER / HOUR
PPB 98.5 PERCENT
t1/2 4 HOUR

TARGET HIV PROTEASE

PDB
1N49 (VIABILITY OF A DRUG-RESISTANT HIV-1 PROTEASE VARIANT: STRUCTURAL INSIGHTS FOR BETTER ANTI-VIRAL THERAPY)

Ligand code = RIT (link to the list of PDB complexes)

Download experimental 3D coordinates of RIT with added hydrogens

MW 720.95
NB_atoms 50
XLogP 5.91
PSA 118.064
NB_HD 4
NB_HA 11
fsp3 0.43
Lipinski(0=no;1=yes) 0

FDA
NDA 020659 (label) INN (RITONAVIR) NORVIR (ABBVIE) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020680 (pdf not found) INN (RITONAVIR) NORVIR (ABBOTT) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020945 (label) INN (RITONAVIR) NORVIR (ABBVIE) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021226 (label) INN (LOPINAVIR ; RITONAVIR) KALETRA (ABBVIE) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 021251 (label) INN (LOPINAVIR ; RITONAVIR) KALETRA (ABBVIE) APPROVAL= AP YEAR= 2000
NDA 021906 (label) INN (LOPINAVIR ; RITONAVIR) KALETRA (ABBVIE) APPROVAL= AP YEAR= 2005
NDA 090371 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (CIPLA LIMITED) APPROVAL= TA YEAR= 2009
NDA 090471 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2009
NDA 022417 (label) INN (RITONAVIR) NORVIR (ABBVIE) APPROVAL= AP YEAR= 2010
NDA 091202 (label) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (MYLAN PHARMA) APPROVAL= TA YEAR= 2011
NDA 022282 (pdf not found) INN (ATAZANAVIR SULFATE ; RITONAVIR) ATAZANAVIR SULFATE AND RITONAVIR (MATRIX LABS LTD) APPROVAL= TA YEAR= 2011
NDA 091203 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (CIPLA LIMITED) APPROVAL= TA YEAR= 2012
NDA 205508 (pdf not found) INN (ATAZANAVIR SULFATE ; RITONAVIR) ATAZANAVIR SULFATE; RITONAVIR (EMCURE PHARMS LTD) APPROVAL= TA YEAR= 2014
NDA 206041 (pdf not found) INN (ATAZANAVIR SULFATE ; RITONAVIR ; LAMIVUDINE ; ZIDOVUDINE) ATAZANAVIR SULFATE;RITONAVIR;LAMIVUDINE;ZIDOVUDINE (MYLAN LABS LTD) APPROVAL= TA YEAR= 2014
NDA 206619 (label) INN (DASABUVIR SODIUM ; OMBITASVIR ; PARITAPREVIR ; RITONAVIR) VIEKIRA PAK COPACKAGED (ABBVIE) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202573 (label) INN (RITONAVIR) RITONAVIR (CIPLA) APPROVAL= AP YEAR= 2015
NDA 205040 (pdf not found) INN (RITONAVIR) RITONAVIR (CIPLA LIMITED) APPROVAL= TA YEAR= 2015
NDA 205425 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (CIPLA LTD) APPROVAL= TA YEAR= 2015
NDA 207931 (label) INN (OMBITASVIR ; PARITAPREVIR ; RITONAVIR) TECHNIVIE (ABBVIE) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 202738 (pdf not found) INN (RITONAVIR) RITONAVIR (MYLAN PHARMS INC) APPROVAL= TA YEAR= 2016
NDA 207407 (label) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (LANNETT CO INC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 208624 (label) INN (DASABUVIR SODIUM ; OMBITASVIR ; PARITAPREVIR ; RITONAVIR) VIEKIRA XR (ABBVIE) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 209512 (label) INN (RITONAVIR) NORVIR (ABBVIE) APPROVAL= AP YEAR= 2017
NDA 206614 (pdf not found) INN (RITONAVIR) RITONAVIR (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2018
NDA 204587 (pdf not found) INN (RITONAVIR) RITONAVIR (HETERO LABS LTD III) APPROVAL= AP YEAR= 2018
NDA 208890 (pdf not found) INN (RITONAVIR) RITONAVIR (AMNEAL) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 205801 (pdf not found) INN (RITONAVIR) RITONAVIR (HIKMA) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 091677 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (HETERO LABS LTD III) APPROVAL= AP YEAR= 2021
NDA 203759 (pdf not found) INN (RITONAVIR) RITONAVIR (CIPLA) APPROVAL= AP YEAR= 2022
NDA 213857 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (LAURUS) APPROVAL= AP YEAR= 2022
NDA 217188 (label) INN (NIRMATRELVIR ; RITONAVIR) PAXLOVID COPACKAGED (PFIZER) APPROVAL= AP YEAR= 2023 NEWMOLECULARENTITY
NDA 209847 (pdf not found) INN (DARUNAVIR ; RITONAVIR) DARUNAVIR AND RITONAVIR (MYLAN PHARMS INC) APPROVAL= TA YEAR= 2023
NDA 079074 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (MYLAN LABS LTD) APPROVAL= AP YEAR= 2024
NDA 204739 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024
NDA 205024 (pdf not found) INN (RITONAVIR) RITONAVIR (QUAGEN) APPROVAL= AP YEAR= 2024
NDA 214696 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (MICRO LABS) APPROVAL= AP YEAR= 2025