e-Drug3D

76

cas 65-49-6

CLASS

ANTIINFECTIVES
ANTITUBERCULOSIS
ANTIBIOTIC
ANTIBACTERIAL
PRODUCTION OF A TOXIC INACTIVE METABOLITE

ROUTE (list)

ORAL

PK parameters

Tmax 6 HOUR
VD 51.8 LITER
Cl 9.42 LITER / HOUR (PMID25114132)
PPB 55 PERCENT
t1/2 3.25 HOUR

TARGET DIHYDROFOLATE REDUCTASE (DHFR) (PMID26848874)

PDB
5X7Z (CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS MARR FAMILY PROTEIN RV2887 COMPLEX WITH P-AMINOSALICYLIC ACID)

Ligand code = BHA (link to the list of PDB complexes)

Download experimental 3D coordinates of BHA with added hydrogens

MW 152.13
NB_atoms 11
XLogP -0.66
PSA 78.174
NB_HD 3
NB_HA 4
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 006811 (pdf not found) INN (AMINOSALICYLIC ACID) PARASAL (PANRAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 009052 (pdf not found) INN (AMINOSALICYLIC ACID RESIN COMPLEX) REZIPAS (BRISTOL MYERS SQUIBB) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080947 (pdf not found) INN (AMINOSALICYLATE SODIUM) P.A.S. SODIUM (CENTURY PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 007320 (pdf not found) INN (AMINOSALICYLATE SODIUM) TEEBACIN (CONSOLIDATED MIDLAND) APPROVAL= AP YEAR= 1950 DISCONTINUED
NDA 009395 (pdf not found) INN (POTASSIUM AMINOSALICYLATE) PASKALIUM (GLENWOOD) APPROVAL= AP YEAR= 1955 DISCONTINUED
NDA 080097 (pdf not found) INN (AMINOSALICYLATE SODIUM) SODIUM AMINOSALICYLATE (HEXCEL) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 080098 (pdf not found) INN (POTASSIUM AMINOSALICYLATE) POTASSIUM AMINOSALICYLATE (HEXCEL) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 080059 (pdf not found) INN (AMINOSALICYLATE SODIUM ; AMINOSALICYLIC ACID) NEOPASALATE (MEDPOINTE PHARM HLC) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 080138 (pdf not found) INN (AMINOSALICYLATE SODIUM) SODIUM P.A.S. (LANNETT) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 074346 (pdf not found) INN (AMINOSALICYLIC ACID) PASER (ADAPTIS) APPROVAL= AP YEAR= 1994