e-Drug3D

746

AMLEXANOX

DISCONTINUED

INN
AMLEXANOX

cas 68302-57-8

CLASS

METABOLISM
ANTI-ALLERGIC
ANTI-INFLAMMATORY
TREATMENT OF APHTHOUS ULCER

ROUTE (list)

DENTAL TOPICAL

ATC code

A01AD07
R03DX01

PK parameters

Tmax 2.4 HOUR
Cmax 402 NANOMOLAR
t1/2 3.5 HOUR

Target

TARGET G PROTEIN-COUPLED RECEPTOR KINASES (GRKS) (PMID25340299)

PDB
2KOT (SOLUTION STRUCTURE OF S100A13 WITH A DRUG AMLEXANOX)

Ligand code = ANW (link to the list of PDB complexes)

Download experimental 3D coordinates of ANW with added hydrogens

DrugCentral

Phosphodiesterase 4 UNIPROT P27815 PDE4A

Download SDF file

2-amino-5-oxo-7-propan-2-ylchromeno[3,2-e]pyridine-3-carboxylic acid

Formula:
C16H14N2O4

Calculated chemical properties:

MW 297.28
NB_atoms 22
XLogP 1.41
PSA 91.43
NB_HD 2
NB_HA 6
fsp3 0.19
Lipinski(0=no;1=yes) 1

FDA
NDA 020511 (label) INN (AMLEXANOX) APHTHASOL (ULURU) APPROVAL= AP YEAR= 1996 NEWMOLECULARENTITY DISCONTINUED
NDA 021727 (label) INN (AMLEXANOX) AMLEXANOX (ULURU) APPROVAL= AP YEAR= 2004 DISCONTINUED