e-Drug3D

722

FAMCICLOVIR

INN
FAMCICLOVIR

(has an active metabolite)

cas 104227-87-4

CLASS

ANTIINFECTIVES
ANTIVIRAL
DNA POLYMERASE INHIBITOR
PRODRUG OF PENCICLOVIR
TREATMENT OF HERPES VIRUS HSV-1 AND HSV-2

ROUTE (list)

ORAL

ATC code

J05AB09
S01AD07

PK parameters

F 77 PERCENT

Solubility

IS FREELY SOLUBLE (>25 PERCENT) IN WATER INITIALLY BUT RAPIDLY PRECIPITATES AS THE SPARINGLY SOLUBLE (2-3 PERCENT) MONOHYDRATE

Target

DrugCentral

DNA polymerase catalytic subunit UNIPROT P04293

Download SDF file

[2-(acetyloxymethyl)-4-(2-aminopurin-9-yl)butyl] acetate

Formula:
C14H19N5O4

Calculated chemical properties:

MW 321.34
NB_atoms 23
XLogP 0.54
PSA 112.592
NB_HD 2
NB_HA 9
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 020363 (label) INN (FAMCICLOVIR) FAMVIR (NOVARTIS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 077487 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (TEVA PHARMS) APPROVAL= AP YEAR= 2007
NDA 090128 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (HIKMA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 078278 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (CIPLA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091114 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2011
NDA 201333 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (NATCO PHARMA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091480 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (APOTEX) APPROVAL= AP YEAR= 2011
NDA 201022 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 202438 (pdf not found) INN (FAMCICLOVIR) FAMCICLOVIR (HETERO LABS LTD V) APPROVAL= AP YEAR= 2014