e-Drug3D

720

NISOLDIPINE

INN
NISOLDIPINE

cas 63675-72-9

CLASS

CARDIOVASCULAR
CORONARY VASODILATOR
ANTIANGINAL
ANTIHYPERTENSIVE AGENTS
CALCIUM CHANNEL BLOCKERS

ROUTE (list)

ORAL

ATC code

C08CA07

PK parameters

F 5 PERCENT
Tmax 9 HOUR
VD 357 LITER (65 KILOGRAM)
Cl 58.5 LITER / HOUR (65 KILOGRAM)
PPB 99 PERCENT
t1/2 9.5 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL

DrugCentral

Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C

Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D

Download SDF file

O5-methyl O3-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Formula:
C20H24N2O6

Calculated chemical properties:

MW 388.41
NB_atoms 28
XLogP 3.20
PSA 99.394
NB_HD 1
NB_HA 7
fsp3 0.40
Lipinski(0=no;1=yes) 1

FDA
NDA 020356 (label) INN (NISOLDIPINE) SULAR (AZURITY) APPROVAL= AP YEAR= 1995 NEWMOLECULARENTITY
NDA 079051 (pdf not found) INN (NISOLDIPINE) NISOLDIPINE (MYLAN) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 091001 (pdf not found) INN (NISOLDIPINE) NISOLDIPINE (MYLAN) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 216606 (pdf not found) INN (NISOLDIPINE) NISOLDIPINE (AMTA) APPROVAL= AP YEAR= 2023