e-Drug3D
705
GRANISETRON
INN
GRANISETRON
cas 109889-09-0
CLASS
METABOLISM
ANTIEMETIC
SEROTONIN (5HT3) ANTAGONISTS
ROUTE (list)
INJECTION ORAL TRANSDERMAL SUBCUTANEOUS
ATC code
A04AA02
PK parameters
VD 197 LITER (65 KILOGRAM)
Cl 51.3 LITER / HOUR (65 KILOGRAM)
PPB 65 PERCENT
t1/2 4.9 HOUR
Solubility
READILY SOLUBLE IN WATER
TARGET 5-HYDROXYTRYPTAMINE 3 RECEPTOR
PDB
2YME (CRYSTAL STRUCTURE OF A MUTANT BINDING PROTEIN (5HTBP-ACHBP) IN COMPLEX WITH GRANISETRON)
Ligand code = CWB (link to the list of PDB complexes)
Download experimental 3D coordinates of CWB with added hydrogens
5-hydroxytryptamine receptor 3A UNIPROT P46098 HTR3A
Formula:
C18H24N4O
Calculated chemical properties:
MW 312.41
NB_atoms 23
XLogP 2.32
PSA 48.65
NB_HD 1
NB_HA 5
fsp3 0.56
Lipinski(0=no;1=yes) 1
NB_atoms 23
XLogP 2.32
PSA 48.65
NB_HD 1
NB_HA 5
fsp3 0.56
Lipinski(0=no;1=yes) 1
FDA
NDA 020239 (label) INN (GRANISETRON HYDROCHLORIDE) KYTRIL (ROCHE) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020305 (label) INN (GRANISETRON HYDROCHLORIDE) KYTRIL (ROCHE) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 021238 (label) INN (GRANISETRON HYDROCHLORIDE) KYTRIL (ROCHE) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 077165 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE PRESERVATIVE FREE (DR REDDYS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077177 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2007
NDA 077842 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078080 (label) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (TEVA PHARMS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078197 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078221 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (BARR) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078260 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078262 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2007
NDA 078392 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2007
NDA 078522 (label) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2007
NDA 022198 (label) INN (GRANISETRON) SANCUSO (CUMBERLAND) APPROVAL= AP YEAR= 2008
NDA 077186 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2008
NDA 077187 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2008
NDA 077297 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2008
NDA 077913 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2008
NDA 077963 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078037 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2008
NDA 078090 (label) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2008
NDA 078096 (label) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE PRESERVATIVE FREE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2008
NDA 078198 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078258 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2008
NDA 078334 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISOL (INTRA SANA LABS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078564 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (WOCKHARDT USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078565 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (WOCKHARDT USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078566 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (WOCKHARDT USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078678 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (ORBION PHARMS) APPROVAL= AP YEAR= 2008
NDA 078725 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078808 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078835 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (SANDOZ INC) APPROVAL= AP YEAR= 2008
NDA 078843 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (APOTEX INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078863 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (BIONPHARMA) APPROVAL= AP YEAR= 2008
NDA 078880 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (BIONPHARMA) APPROVAL= AP YEAR= 2008
NDA 078531 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 078534 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 078629 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2009
NDA 078846 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2009
NDA 078969 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (NATCO PHARMA) APPROVAL= AP YEAR= 2009
NDA 079078 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2009
NDA 079119 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 091136 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (MYLAN ASI) APPROVAL= AP YEAR= 2010
NDA 091137 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (MYLAN ASI) APPROVAL= AP YEAR= 2010
NDA 090817 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (TARO) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 091274 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (AM REGENT) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 022445 (label) INN (GRANISETRON) SUSTOL (HERON THERAPS INC) APPROVAL= AP YEAR= 2016
NDA 204238 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203453 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 203454 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 202647 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (YUNG SHIN PHARM) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 202648 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (YUNG SHIN PHARM) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 219282 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (INTRA SANA LABS) APPROVAL= AP YEAR= 2025
NDA 020239 (label) INN (GRANISETRON HYDROCHLORIDE) KYTRIL (ROCHE) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020305 (label) INN (GRANISETRON HYDROCHLORIDE) KYTRIL (ROCHE) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 021238 (label) INN (GRANISETRON HYDROCHLORIDE) KYTRIL (ROCHE) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 077165 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE PRESERVATIVE FREE (DR REDDYS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077177 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2007
NDA 077842 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078080 (label) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (TEVA PHARMS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078197 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078221 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (BARR) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078260 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078262 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2007
NDA 078392 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2007
NDA 078522 (label) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2007
NDA 022198 (label) INN (GRANISETRON) SANCUSO (CUMBERLAND) APPROVAL= AP YEAR= 2008
NDA 077186 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2008
NDA 077187 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2008
NDA 077297 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2008
NDA 077913 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2008
NDA 077963 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078037 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2008
NDA 078090 (label) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2008
NDA 078096 (label) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE PRESERVATIVE FREE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2008
NDA 078198 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078258 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2008
NDA 078334 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISOL (INTRA SANA LABS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078564 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (WOCKHARDT USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078565 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (WOCKHARDT USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078566 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (WOCKHARDT USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078678 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (ORBION PHARMS) APPROVAL= AP YEAR= 2008
NDA 078725 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078808 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078835 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (SANDOZ INC) APPROVAL= AP YEAR= 2008
NDA 078843 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (APOTEX INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078863 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (BIONPHARMA) APPROVAL= AP YEAR= 2008
NDA 078880 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (BIONPHARMA) APPROVAL= AP YEAR= 2008
NDA 078531 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 078534 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 078629 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2009
NDA 078846 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2009
NDA 078969 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (NATCO PHARMA) APPROVAL= AP YEAR= 2009
NDA 079078 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2009
NDA 079119 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 091136 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (MYLAN ASI) APPROVAL= AP YEAR= 2010
NDA 091137 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (MYLAN ASI) APPROVAL= AP YEAR= 2010
NDA 090817 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (TARO) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 091274 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (AM REGENT) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 022445 (label) INN (GRANISETRON) SUSTOL (HERON THERAPS INC) APPROVAL= AP YEAR= 2016
NDA 204238 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203453 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 203454 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 202647 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (YUNG SHIN PHARM) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 202648 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (YUNG SHIN PHARM) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 219282 (pdf not found) INN (GRANISETRON HYDROCHLORIDE) GRANISETRON HYDROCHLORIDE (INTRA SANA LABS) APPROVAL= AP YEAR= 2025