e-Drug3D

700

cas 145040-37-5

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
HYDROLYZED TO CANDESARTAN DURING ABSORPTION FROM THE GASTROINTESTINAL TRACT
CANDESARTAN IS A SELECTIVE AT1 SUBTYPE ANGIOTENSIN II RECEPTOR ANTAGONIST
CANDESARTAN BLOCKS THE VASOCONSTRICTOR AND ALDOSTERONE-SECRETING EFFECTS OF ANGIOTENSIN II

ROUTE (list)

ORAL

PK parameters

MW 610.66
NB_atoms 45
XLogP 6.32
PSA 105.021
NB_HD 1
NB_HA 12
fsp3 0.33
Lipinski(0=no;1=yes) 0

FDA
NDA 020838 (label) INN (CANDESARTAN CILEXETIL) ATACAND (ANI PHARMS) APPROVAL= AP YEAR= 1998
NDA 021093 (label) INN (CANDESARTAN CILEXETIL ; HYDROCHLOROTHIAZIDE) ATACAND HCT (ANI PHARMS) APPROVAL= AP YEAR= 2000
NDA 090434 (pdf not found) INN (CANDESARTAN CILEXETIL) CANDESARTAN CILEXETIL (MATRIX LABS LTD) APPROVAL= TA YEAR= 2011 OBSOLETE
NDA 090704 (pdf not found) INN (CANDESARTAN CILEXETIL ; HYDROCHLOROTHIAZIDE) CANDESARTAN CILEXETIL AND HYDROCHLOROTHIAZIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2012
NDA 200887 (pdf not found) INN (CANDESARTAN CILEXETIL ; HYDROCHLOROTHIAZIDE) CANDESARTAN CILEXETIL; HYDROCHLOROTHIAZIDE (TEVA PHARMS USA) APPROVAL= TA YEAR= 2012
NDA 202884 (pdf not found) INN (CANDESARTAN CILEXETIL ; HYDROCHLOROTHIAZIDE) CANDESARTAN CILEXETIL AND HYDROCHLOROTHIAZIDE (APOTEX INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078702 (pdf not found) INN (CANDESARTAN CILEXETIL) CANDESARTAN CILEXETIL (MYLAN) APPROVAL= AP YEAR= 2013
NDA 202965 (pdf not found) INN (CANDESARTAN CILEXETIL ; HYDROCHLOROTHIAZIDE) CANDESARTAN CILEXETIL AND HYDROCHLOROTHIAZIDE (SENORES PHARMS) APPROVAL= AP YEAR= 2013
NDA 202079 (pdf not found) INN (CANDESARTAN CILEXETIL) CANDESARTAN CILEXETIL (APOTEX) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 204100 (pdf not found) INN (CANDESARTAN CILEXETIL ; HYDROCHLOROTHIAZIDE) CANDESARTAN CILEXETIL AND HYDROCHLOROTHIAZIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2015
NDA 203813 (pdf not found) INN (CANDESARTAN CILEXETIL) CANDESARTAN CILEXETIL (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2016
NDA 209119 (pdf not found) INN (CANDESARTAN CILEXETIL) CANDESARTAN CILEXETIL (ALEMBIC) APPROVAL= AP YEAR= 2017
NDA 091390 (pdf not found) INN (CANDESARTAN CILEXETIL) CANDESARTAN CILEXETIL (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2017
NDA 203466 (pdf not found) INN (CANDESARTAN CILEXETIL ; HYDROCHLOROTHIAZIDE) CANDESARTAN CILEXETIL AND HYDROCHLOROTHIAZIDE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2017
NDA 207455 (pdf not found) INN (CANDESARTAN CILEXETIL ; HYDROCHLOROTHIAZIDE) CANDESARTAN CILEXETIL AND HYDROCHLOROTHIAZIDE (PRINSTON INC) APPROVAL= AP YEAR= 2018
NDA 210302 (pdf not found) INN (CANDESARTAN CILEXETIL) CANDESARTAN CILEXETIL (ALEMBIC) APPROVAL= AP YEAR= 2018
NDA 206233 (pdf not found) INN (CANDESARTAN CILEXETIL) CANDESARTAN CILEXETIL (PRINSTON INC) APPROVAL= AP YEAR= 2023