e-Drug3D

697

DEXRAZOXANE

INN
DEXRAZOXANE

cas 24584-09-6

CLASS

VARIOUS
CARDIOPROTECTIVE
CHELATING AGENTS
CYCLIC DERIVATIVE OF EDTA
EXTRAVASATION OF ANTHRACYCLINE DRUGS
CATALYTIC TOPOISOMERASE II INHIBITOR (PMID25521189)

ROUTE (list)

INJECTION

ATC code

V03AF02

PK parameters

VD 35.4 LITER
Cl 10 LITER / HOUR
PPB 0 PERCENT
t1/2 2.1 HOUR

Solubility

SPARINGLY SOLUBLE IN WATER

Target

TARGET TOPOISOMERASE II

DrugCentral

Unknown

Download SDF file

4-[(2S)-1-(3,5-dioxopiperazin-1-yl)propan-2-yl]piperazine-2,6-dione

Formula:
C11H16N4O4

Calculated chemical properties:

MW 268.28
NB_atoms 19
XLogP -2.71
PSA 108.201
NB_HD 2
NB_HA 8
fsp3 0.64
Lipinski(0=no;1=yes) 1

FDA
NDA 020212 (label) INN (DEXRAZOXANE HYDROCHLORIDE) ZINECARD (PFIZER) APPROVAL= AP YEAR= 1995 NEWMOLECULARENTITY DISCONTINUED
NDA 076068 (pdf not found) INN (DEXRAZOXANE HYDROCHLORIDE) DEXRAZOXANE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2004
NDA 022025 (label) INN (DEXRAZOXANE HYDROCHLORIDE) TOTECT (CLINIGEN) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 200752 (pdf not found) INN (DEXRAZOXANE HYDROCHLORIDE) DEXRAZOXANE HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2011
NDA 207321 (pdf not found) INN (DEXRAZOXANE HYDROCHLORIDE) DEXRAZOXANE HYDROCHLORIDE (GLAND) APPROVAL= AP YEAR= 2016
NDA 216748 (pdf not found) INN (DEXRAZOXANE HYDROCHLORIDE) DEXRAZOXANE HYDROCHLORIDE (MSN) APPROVAL= AP YEAR= 2025