e-Drug3D

666

cas 61869-08-7

CLASS

NERVOUS SYSTEM
ANTIDEPRESSANTS
SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS)

ROUTE (list)

ORAL

PK parameters

Tmax 5.2 HOUR
Cmax 187 NANOMOLAR
VD 1170 LITER (65 KILOGRAM)
Cl 70.2 LITER / HOUR (65 KILOGRAM)
PPB 94 PERCENT
t1/2 21 HOUR

TARGET SEROTONIN TRANSPORTER

PDB
6F6I (CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH PAROXETINE)

Ligand code = 8PR (link to the list of PDB complexes)

Download experimental 3D coordinates of 8PR with added hydrogens

MW 329.36
NB_atoms 24
XLogP 3.33
PSA 48.133
NB_HD 1
NB_HA 4
fsp3 0.37
Lipinski(0=no;1=yes) 1

FDA
NDA 020031 (label) INN (PAROXETINE HYDROCHLORIDE) PAXIL (APOTEX) APPROVAL= AP YEAR= 1992
NDA 020710 (label) INN (PAROXETINE HYDROCHLORIDE) PAXIL (APOTEX) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 020885 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAXIL (APOTEX) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 020936 (label) INN (PAROXETINE HYDROCHLORIDE) PAXIL CR (APOTEX) APPROVAL= AP YEAR= 1999
NDA 021299 (label) INN (PAROXETINE MESYLATE) PEXEVA (SEBELA IRELAND LTD) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 075356 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2003
NDA 075566 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 075716 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076618 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2005
NDA 077395 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (APOTEX INC) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077082 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (TEVA PHARMS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077584 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (ZYDUS PHARMS USA) APPROVAL= AP YEAR= 2007
NDA 077873 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2007
NDA 078026 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (ROXANE) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078194 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078406 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2007
NDA 078902 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (MYLAN) APPROVAL= AP YEAR= 2008
NDA 076968 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (OXFORD PHARMS) APPROVAL= AP YEAR= 2010
NDA 091427 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2011
NDA 204516 (label) INN (PAROXETINE MESYLATE) BRISDELLE (LEGACY) APPROVAL= AP YEAR= 2013
NDA 203854 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE (PRINSTON INC) APPROVAL= AP YEAR= 2014
NDA 205528 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 204744 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (LANNETT CO INC) APPROVAL= AP YEAR= 2016
NDA 204134 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (LUPIN) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207139 (label) INN (PAROXETINE MESYLATE) PAROXETINE MESYLATE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2017
NDA 207188 (pdf not found) INN (PAROXETINE MESYLATE) PAROXETINE MESYLATE (PRINSTON INC) APPROVAL= AP YEAR= 2017
NDA 209293 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (SCIECURE PHARMA INC) APPROVAL= AP YEAR= 2018
NDA 213485 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (CSPC OUYI) APPROVAL= AP YEAR= 2021
NDA 211248 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (YILING) APPROVAL= AP YEAR= 2021
NDA 212645 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2021
NDA 213612 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 215003 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2021
NDA 209748 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (PRINSTON INC) APPROVAL= AP YEAR= 2024
NDA 217280 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2025
NDA 219954 (pdf not found) INN (PAROXETINE HYDROCHLORIDE) PAROXETINE HYDROCHLORIDE (ANNORA PHARMA) APPROVAL= AP YEAR= 2026