e-Drug3D
611
cas 42924-53-8
CLASS
MUSCULO-SKELETAL
ANTIINFLAMMATORY
NSAID
ANALGESIC
ANTIPYRETIC
ROUTE (list)
ORAL
ATC code
M01AX01
PK parameters
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2
PROSTAGLANDIN G/H SYNTHASE 2
PDB
3TAJ (CRYSTAL STRUCTURE OF C-LOBE OF BOVINE LACTOFERRIN COMPLEXED WITH NABUMETONE AT 1.7A RESOLUTION)
Ligand code = NBO (link to the list of PDB complexes)
Download experimental 3D coordinates of NBO with added hydrogens
Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2
Formula:
C15H16O2
Calculated chemical properties:
MW 228.28
NB_atoms 17
XLogP 3.37
PSA 27.35
NB_HD 0
NB_HA 2
fsp3 0.27
Lipinski(0=no;1=yes) 1
NB_atoms 17
XLogP 3.37
PSA 27.35
NB_HD 0
NB_HA 2
fsp3 0.27
Lipinski(0=no;1=yes) 1
FDA
NDA 019583 (label) INN (NABUMETONE) RELAFEN (SMITHKLINE BEECHAM) APPROVAL= AP YEAR= 1991 NEWMOLECULARENTITY DISCONTINUED
NDA 075179 (label) INN (NABUMETONE) NABUMETONE (COPLEY PHARM) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075189 (label) INN (NABUMETONE) NABUMETONE (IMPAX LABS INC) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075280 (pdf not found) INN (NABUMETONE) NABUMETONE (CHARTWELL RX) APPROVAL= AP YEAR= 2002
NDA 075590 (pdf not found) INN (NABUMETONE) NABUMETONE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076009 (pdf not found) INN (NABUMETONE) NABUMETONE (CHARTWELL MOLECULES) APPROVAL= AP YEAR= 2003
NDA 078671 (pdf not found) INN (NABUMETONE) NABUMETONE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2008
NDA 078420 (pdf not found) INN (NABUMETONE) NABUMETONE (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2008
NDA 079093 (pdf not found) INN (NABUMETONE) NABUMETONE (OXFORD PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090516 (pdf not found) INN (NABUMETONE) NABUMETONE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090445 (pdf not found) INN (NABUMETONE) NABUMETONE (ANNORA PHARMA) APPROVAL= AP YEAR= 2011
NDA 091083 (pdf not found) INN (NABUMETONE) NABUMETONE (WATSON LABS) APPROVAL= AP YEAR= 2011
NDA 090427 (pdf not found) INN (NABUMETONE) NABUMETONE (SENORES PHARMS) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 203166 (pdf not found) INN (NABUMETONE) NABUMETONE (LGM PHARMA) APPROVAL= AP YEAR= 2019
NDA 219118 (pdf not found) INN (NABUMETONE) NABUMETONE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2025
NDA 019583 (label) INN (NABUMETONE) RELAFEN (SMITHKLINE BEECHAM) APPROVAL= AP YEAR= 1991 NEWMOLECULARENTITY DISCONTINUED
NDA 075179 (label) INN (NABUMETONE) NABUMETONE (COPLEY PHARM) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075189 (label) INN (NABUMETONE) NABUMETONE (IMPAX LABS INC) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075280 (pdf not found) INN (NABUMETONE) NABUMETONE (CHARTWELL RX) APPROVAL= AP YEAR= 2002
NDA 075590 (pdf not found) INN (NABUMETONE) NABUMETONE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076009 (pdf not found) INN (NABUMETONE) NABUMETONE (CHARTWELL MOLECULES) APPROVAL= AP YEAR= 2003
NDA 078671 (pdf not found) INN (NABUMETONE) NABUMETONE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2008
NDA 078420 (pdf not found) INN (NABUMETONE) NABUMETONE (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2008
NDA 079093 (pdf not found) INN (NABUMETONE) NABUMETONE (OXFORD PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090516 (pdf not found) INN (NABUMETONE) NABUMETONE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090445 (pdf not found) INN (NABUMETONE) NABUMETONE (ANNORA PHARMA) APPROVAL= AP YEAR= 2011
NDA 091083 (pdf not found) INN (NABUMETONE) NABUMETONE (WATSON LABS) APPROVAL= AP YEAR= 2011
NDA 090427 (pdf not found) INN (NABUMETONE) NABUMETONE (SENORES PHARMS) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 203166 (pdf not found) INN (NABUMETONE) NABUMETONE (LGM PHARMA) APPROVAL= AP YEAR= 2019
NDA 219118 (pdf not found) INN (NABUMETONE) NABUMETONE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2025