e-Drug3D

607

cas 76547-98-3

CLASS

CARDIOVASCULAR
ANGIOTENSIN-CONVERTING ENZYME INHIBITOR (ACE)
ANTIHYPERTENSIVE
CARDIOTONIC AGENTS

ROUTE (list)

ORAL

PK parameters

F 25 PERCENT
Tmax 7 HOUR
VD 57.8 LITER
Cl 4.6 LITER / HOUR
PPB 0 PERCENT
t1/2 42 HOUR

TARGET ANGIOTENSIN-CONVERTING ENZYME

PDB
1O86 (CRYSTAL STRUCTURE OF HUMAN ANGIOTENSIN CONVERTING ENZYME IN COMPLEX WITH LISINOPRIL.)

Ligand code = LPR (link to the list of PDB complexes)

Download experimental 3D coordinates of LPR with added hydrogens

MW 403.47
NB_atoms 29
XLogP -1.43
PSA 121.002
NB_HD 3
NB_HA 8
fsp3 0.57
Lipinski(0=no;1=yes) 1

FDA
NDA 019558 (label) INN (LISINOPRIL) PRINIVIL (MERCK) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 019777 (label) INN (LISINOPRIL) ZESTRIL (TWI PHARMS) APPROVAL= AP YEAR= 1988
NDA 019778 (label) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) PRINZIDE (MERCK) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 019888 (label) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) ZESTORETIC (ALMATICA) APPROVAL= AP YEAR= 1989
NDA 075743 (pdf not found) INN (LISINOPRIL) LISINOPRIL (PRINSTON INC) APPROVAL= AP YEAR= 2002
NDA 075752 (pdf not found) INN (LISINOPRIL) LISINOPRIL (HERITAGE PHARMA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075776 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075783 (pdf not found) INN (LISINOPRIL) LISINOPRIL (TEVA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075869 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (TEVA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075903 (pdf not found) INN (LISINOPRIL) LISINOPRIL (ANNORA PHARMA) APPROVAL= AP YEAR= 2002
NDA 075926 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075944 (pdf not found) INN (LISINOPRIL) LISINOPRIL (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2002
NDA 075994 (pdf not found) INN (LISINOPRIL) LISINOPRIL (CHARTWELL RX) APPROVAL= AP YEAR= 2002
NDA 075999 (pdf not found) INN (LISINOPRIL) LISINOPRIL (RISING) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076007 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2002
NDA 076059 (pdf not found) INN (LISINOPRIL) LISINOPRIL (WATSON LABS) APPROVAL= AP YEAR= 2002
NDA 076063 (pdf not found) INN (LISINOPRIL) LISINOPRIL (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076071 (pdf not found) INN (LISINOPRIL) LISINOPRIL (STRIDES PHARMA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076102 (pdf not found) INN (LISINOPRIL) LISINOPRIL (COREPHARMA) APPROVAL= AP YEAR= 2002
NDA 076113 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076164 (pdf not found) INN (LISINOPRIL) LISINOPRIL (PRINSTON INC) APPROVAL= AP YEAR= 2002
NDA 076180 (pdf not found) INN (LISINOPRIL) LISINOPRIL (PRINSTON INC) APPROVAL= AP YEAR= 2002 OBSOLETE
NDA 076194 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 2002
NDA 076230 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (PRINSTON INC) APPROVAL= AP YEAR= 2002
NDA 076262 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (AIPING PHARM INC) APPROVAL= AP YEAR= 2002
NDA 076265 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076674 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (COREPHARMA) APPROVAL= AP YEAR= 2004
NDA 077321 (pdf not found) INN (LISINOPRIL) LISINOPRIL (LUPIN) APPROVAL= AP YEAR= 2005
NDA 077606 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (AUROBINDO) APPROVAL= AP YEAR= 2006
NDA 077622 (pdf not found) INN (LISINOPRIL) LISINOPRIL (AUROBINDO) APPROVAL= AP YEAR= 2006
NDA 077912 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (LUPIN) APPROVAL= AP YEAR= 2006
NDA 078402 (pdf not found) INN (LISINOPRIL) LISINOPRIL (WOCKHARDT BIO AG) APPROVAL= AP YEAR= 2007
NDA 202554 (pdf not found) INN (LISINOPRIL) LISINOPRIL (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 203508 (pdf not found) INN (LISINOPRIL) LISINOPRIL (INVAGEN PHARMS) APPROVAL= AP YEAR= 2013
NDA 208401 (label) INN (LISINOPRIL) QBRELIS (AZURITY) APPROVAL= AP YEAR= 2016
NDA 204058 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; LISINOPRIL) LISINOPRIL AND HYDROCHLOROTHIAZIDE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2017
NDA 212041 (pdf not found) INN (LISINOPRIL) LISINOPRIL (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2020
NDA 208920 (pdf not found) INN (LISINOPRIL) LISINOPRIL (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2021