e-Drug3D
601
NICARDIPINE
INN
NICARDIPINE
cas 55985-32-5
CLASS
CARDIOVASCULAR
VASODILATOR
ANTIARRHYTHMIC AGENTS
ANTIHYPERTENSIVE AGENTS
CALCIUM CHANNEL BLOCKERS
DIHYDROPYRIDINES
ROUTE (list)
ORAL INJECTION INTRAVENOUS
ATC code
C08CA04
PK parameters
F 35 PERCENT
Tmax 1 HOUR
VD 539 LITER (65 KILOGRAM)
Cl 26 LITER / HOUR (65 KILOGRAM)
PPB 95 PERCENT
t1/2 4.1 HOUR
Solubility
SLIGHTLY SOLUBLE IN WATER
TARGET VOLTAGE-DEPENDENT CALCIUM CHANNEL
Voltage-gated L-type calcium channel UNIPROT Q01668 CACNA1D
Formula:
C26H29N3O6
Calculated chemical properties:
MW 479.52
NB_atoms 35
XLogP 3.68
PSA 107.454
NB_HD 1
NB_HA 8
fsp3 0.31
Lipinski(0=no;1=yes) 1
NB_atoms 35
XLogP 3.68
PSA 107.454
NB_HD 1
NB_HA 8
fsp3 0.31
Lipinski(0=no;1=yes) 1
FDA
NDA 019488 (label) INN (NICARDIPINE HYDROCHLORIDE) CARDENE (CHIESI) APPROVAL= AP YEAR= 1988 NEWMOLECULARENTITY DISCONTINUED
NDA 019734 (label) INN (NICARDIPINE HYDROCHLORIDE) CARDENE (CHIESI) APPROVAL= AP YEAR= 1992
NDA 020005 (label) INN (NICARDIPINE HYDROCHLORIDE) CARDENE SR (CHIESI) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 074439 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074540 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074642 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074670 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1996
NDA 074928 (label) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1998
NDA 022276 (label) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 2008
NDA 078405 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 078714 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090125 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (NAVINTA LLC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090534 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (AM REGENT) APPROVAL= AP YEAR= 2009
NDA 090664 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2009
NDA 090671 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2009
NDA 211121 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2021
NDA 216357 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2022
NDA 217555 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (BIONPHARMA) APPROVAL= AP YEAR= 2023
NDA 215377 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (SENORES PHARMS) APPROVAL= AP YEAR= 2023
NDA 216420 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (MICRO LABS) APPROVAL= AP YEAR= 2023
NDA 203978 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE IN 0.86% SODIUM CHLORIDE (INFORLIFE) APPROVAL= AP YEAR= 2024
NDA 218202 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2024
NDA 215406 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 215592 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE (CIPLA) APPROVAL= AP YEAR= 2024
NDA 217548 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (CHENGDU SHUODE) APPROVAL= AP YEAR= 2024
NDA 216819 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (NANJING KING FRIEND) APPROVAL= AP YEAR= 2025
NDA 218638 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (NAVINTA LLC) APPROVAL= AP YEAR= 2025 DISCONTINUED
NDA 219608 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (QILU PHARM HAINAN) APPROVAL= AP YEAR= 2025
NDA 220243 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE (CAPLIN) APPROVAL= AP YEAR= 2025
NDA 019488 (label) INN (NICARDIPINE HYDROCHLORIDE) CARDENE (CHIESI) APPROVAL= AP YEAR= 1988 NEWMOLECULARENTITY DISCONTINUED
NDA 019734 (label) INN (NICARDIPINE HYDROCHLORIDE) CARDENE (CHIESI) APPROVAL= AP YEAR= 1992
NDA 020005 (label) INN (NICARDIPINE HYDROCHLORIDE) CARDENE SR (CHIESI) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 074439 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074540 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074642 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074670 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 1996
NDA 074928 (label) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1998
NDA 022276 (label) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 2008
NDA 078405 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 078714 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090125 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (NAVINTA LLC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090534 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (AM REGENT) APPROVAL= AP YEAR= 2009
NDA 090664 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2009
NDA 090671 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (MANKIND PHARMA) APPROVAL= AP YEAR= 2009
NDA 211121 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2021
NDA 216357 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2022
NDA 217555 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (BIONPHARMA) APPROVAL= AP YEAR= 2023
NDA 215377 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (SENORES PHARMS) APPROVAL= AP YEAR= 2023
NDA 216420 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (MICRO LABS) APPROVAL= AP YEAR= 2023
NDA 203978 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE IN 0.86% SODIUM CHLORIDE (INFORLIFE) APPROVAL= AP YEAR= 2024
NDA 218202 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2024
NDA 215406 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 215592 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE (CIPLA) APPROVAL= AP YEAR= 2024
NDA 217548 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (CHENGDU SHUODE) APPROVAL= AP YEAR= 2024
NDA 216819 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (NANJING KING FRIEND) APPROVAL= AP YEAR= 2025
NDA 218638 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (NAVINTA LLC) APPROVAL= AP YEAR= 2025 DISCONTINUED
NDA 219608 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE (QILU PHARM HAINAN) APPROVAL= AP YEAR= 2025
NDA 220243 (pdf not found) INN (NICARDIPINE HYDROCHLORIDE) NICARDIPINE HYDROCHLORIDE IN 0.9% SODIUM CHLORIDE (CAPLIN) APPROVAL= AP YEAR= 2025