e-Drug3D

591

NORFLOXACIN

DISCONTINUED

INN
NORFLOXACIN

cas 70458-96-7

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
NUCLEIC ACID SYNTHESIS INHIBITORS
QUINOLONES

ROUTE (list)

ORAL OPHTHALMIC

ATC code

J01MA06
S01AE02
J01RA14
J01RA13

PK parameters

F 35 PERCENT
Tmax 1 HOUR
t1/2 3.5 HOUR

Solubility

VERY SLIGHTLY SOLUBLE IN WATER

Target

TARGET DNA GYRASE

DrugCentral

DNA topoisomerase 4 subunit A UNIPROT P0AFI2 parC

DNA gyrase subunit A UNIPROT P0AES4 gyrA

Download SDF file

1-ethyl-6-fluoro-4-oxo-7-piperazin-1-ylquinoline-3-carboxylic acid

Formula:
C16H18FN3O3

Calculated chemical properties:

MW 318.33
NB_atoms 23
XLogP -0.07
PSA 73.071
NB_HD 1
NB_HA 6
fsp3 0.38
Lipinski(0=no;1=yes) 1

FDA
NDA 019384 (label) INN (NORFLOXACIN) NOROXIN (MERCK) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 019757 (label) INN (NORFLOXACIN) CHIBROXIN (MERCK) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 074690 (pdf not found) INN (NORFLOXACIN) NORFLOXACIN (NOVOPHARM LIMITED) APPROVAL= TA YEAR= 2000 OBSOLETE