e-Drug3D
586
SELEGILINE
INN
SELEGILINE
cas 14611-51-9
CLASS
NERVOUS SYSTEM
ANTIPARKINSONIAN
ENZYME INHIBITOR MAO
ANTIDYSKINETICS
CENTRAL NERVOUS SYSTEM AGENTS
COVALENT BINDING
ALSO INCREASE DOPAMINERGIC ACTIVITY
ROUTE (list)
ORAL TRANSDERMAL
ATC code
N04BD01
PK parameters
VD 123.5 LITER (65 KILOGRAM)
Cl 84 LITER / HOUR
PPB 90 PERCENT
t1/2 2 HOUR (SINGLE DOSE)
Solubility
FREELY SOLUBLE IN WATER
TARGET MONOAMINE OXIDASE TYPE B
Amine oxidase flavin-containing B UNIPROT P27338 MAOB
Formula:
C13H17N
Calculated chemical properties:
MW 187.28
NB_atoms 14
XLogP 2.18
PSA 4.837
NB_HD 0
NB_HA 1
fsp3 0.38
Lipinski(0=no;1=yes) 1
NB_atoms 14
XLogP 2.18
PSA 4.837
NB_HD 0
NB_HA 1
fsp3 0.38
Lipinski(0=no;1=yes) 1
FDA
NDA 019334 (label) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (QUAGEN) APPROVAL= AP YEAR= 1989 NEWMOLECULARENTITY DISCONTINUED
NDA 020647 (label) INN (SELEGILINE HYDROCHLORIDE) ELDEPRYL (QUAGEN) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074537 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (G AND W LABS INC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074565 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (CHARTWELL MOLECULES) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074641 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (CHARTWELL MOLECULES) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074672 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (I3 PHARMS) APPROVAL= AP YEAR= 1997
NDA 074744 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074866 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074871 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 1997
NDA 074756 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 074912 (label) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (KENTON) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075321 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 1998
NDA 075352 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 1998
NDA 075145 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (LANNETT CO INC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 021336 (label) INN (SELEGILINE) EMSAM (SOMERSET) APPROVAL= AP YEAR= 2006
NDA 021479 (label) INN (SELEGILINE HYDROCHLORIDE) ZELAPAR (BAUSCH) APPROVAL= AP YEAR= 2006
NDA 021708 (label) INN (SELEGILINE) EMSAM (SOMERSET) APPROVAL= AP YEAR= 2006 NEWAPPLICATION
NDA 206803 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2019
NDA 019334 (label) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (QUAGEN) APPROVAL= AP YEAR= 1989 NEWMOLECULARENTITY DISCONTINUED
NDA 020647 (label) INN (SELEGILINE HYDROCHLORIDE) ELDEPRYL (QUAGEN) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074537 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (G AND W LABS INC) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074565 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (CHARTWELL MOLECULES) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074641 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (CHARTWELL MOLECULES) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074672 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (I3 PHARMS) APPROVAL= AP YEAR= 1997
NDA 074744 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074866 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074871 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 1997
NDA 074756 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 074912 (label) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (KENTON) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075321 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 1998
NDA 075352 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 1998
NDA 075145 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (LANNETT CO INC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 021336 (label) INN (SELEGILINE) EMSAM (SOMERSET) APPROVAL= AP YEAR= 2006
NDA 021479 (label) INN (SELEGILINE HYDROCHLORIDE) ZELAPAR (BAUSCH) APPROVAL= AP YEAR= 2006
NDA 021708 (label) INN (SELEGILINE) EMSAM (SOMERSET) APPROVAL= AP YEAR= 2006 NEWAPPLICATION
NDA 206803 (pdf not found) INN (SELEGILINE HYDROCHLORIDE) SELEGILINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2019