e-Drug3D
560
NALTREXONE
INN
NALTREXONE
cas 16590-41-3
CLASS
NERVOUS SYSTEM
NARCOTIC ANTAGONIST
OPIATE ANTAGONISTS
TREATMENT OF ALCOHOL DEPENDENCE
ROUTE (list)
ORAL INTRAMUSCULAR
PK parameters
F 22 PERCENT
Tmax 2 HOUR
VD 1350 LITER
Cl 210 LITER / HOUR
PPB 21 PERCENT
t1/2 4 HOUR
Solubility
INSOLUBLE IN WATER
TARGET MU-TYPE OPIOID RECEPTOR
Mu-type opioid receptor UNIPROT P35372 OPRM1
Kappa-type opioid receptor UNIPROT P41145 OPRK1
Formula:
C20H23NO4
Calculated chemical properties:
MW 341.39
NB_atoms 25
XLogP 1.53
PSA 74.085
NB_HD 2
NB_HA 5
fsp3 0.65
Lipinski(0=no;1=yes) 1
NB_atoms 25
XLogP 1.53
PSA 74.085
NB_HD 2
NB_HA 5
fsp3 0.65
Lipinski(0=no;1=yes) 1
FDA
NDA 018932 (label) INN (NALTREXONE HYDROCHLORIDE) REVIA (TEVA WOMENS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 074918 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (BARR) APPROVAL= AP YEAR= 1998
NDA 075274 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (ELITE LABS) APPROVAL= AP YEAR= 1999
NDA 075434 (label) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 076264 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (SPECGX LLC) APPROVAL= AP YEAR= 2002
NDA 021897 (label) INN (NALTREXONE) VIVITROL (ALKERMES) APPROVAL= AP YEAR= 2006
NDA 022321 (label) INN (MORPHINE SULFATE ; NALTREXONE HYDROCHLORIDE) EMBEDA (ALPHARMA PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 091205 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2011
NDA 090356 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2012
NDA 200063 (label) INN (BUPROPION HYDROCHLORIDE ; NALTREXONE HYDROCHLORIDE) CONTRAVE (NALPROPION) APPROVAL= AP YEAR= 2014
NDA 207621 (label) INN (NALTREXONE HYDROCHLORIDE ; OXYCODONE HYDROCHLORIDE) TROXYCA ER (PFIZER) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 207905 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (CHARTWELL) APPROVAL= AP YEAR= 2017
NDA 208043 (pdf not found) INN (NALTREXONE HYDROCHLORIDE ; BUPROPION HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE; BUPROPION HYDROCHLORIDE (ACTAVIS LABS FL INC) APPROVAL= TA YEAR= 2022
NDA 213195 (pdf not found) INN (NALTREXONE) NALTREXONE (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 018932 (label) INN (NALTREXONE HYDROCHLORIDE) REVIA (TEVA WOMENS) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 074918 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (BARR) APPROVAL= AP YEAR= 1998
NDA 075274 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (ELITE LABS) APPROVAL= AP YEAR= 1999
NDA 075434 (label) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 076264 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (SPECGX LLC) APPROVAL= AP YEAR= 2002
NDA 021897 (label) INN (NALTREXONE) VIVITROL (ALKERMES) APPROVAL= AP YEAR= 2006
NDA 022321 (label) INN (MORPHINE SULFATE ; NALTREXONE HYDROCHLORIDE) EMBEDA (ALPHARMA PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 091205 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2011
NDA 090356 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2012
NDA 200063 (label) INN (BUPROPION HYDROCHLORIDE ; NALTREXONE HYDROCHLORIDE) CONTRAVE (NALPROPION) APPROVAL= AP YEAR= 2014
NDA 207621 (label) INN (NALTREXONE HYDROCHLORIDE ; OXYCODONE HYDROCHLORIDE) TROXYCA ER (PFIZER) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 207905 (pdf not found) INN (NALTREXONE HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE (CHARTWELL) APPROVAL= AP YEAR= 2017
NDA 208043 (pdf not found) INN (NALTREXONE HYDROCHLORIDE ; BUPROPION HYDROCHLORIDE) NALTREXONE HYDROCHLORIDE; BUPROPION HYDROCHLORIDE (ACTAVIS LABS FL INC) APPROVAL= TA YEAR= 2022
NDA 213195 (pdf not found) INN (NALTREXONE) NALTREXONE (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2023 DISCONTINUED