e-Drug3D
522
GUANABENZ
DISCONTINUED
INN
GUANABENZ
cas 5051-62-7
CLASS
CARDIOVASCULAR
ANTIHYPERTENSIVE
ADRENERGIC ALPHA 2 AGONISTS
SYMPATHOLYTICS
ROUTE (list)
ORAL
ATC code
PK parameters
F 75 PERCENT
Tmax 3.5 HOUR
t1/2 6 HOUR
Solubility
SPARINGLY SOLUBLE IN WATER
TARGET ALPHA 2 ADRENERGIC RECEPTOR
Alpha-2A adrenergic receptor UNIPROT P08913 ADRA2A
Alpha-2B adrenergic receptor UNIPROT P18089 ADRA2B
Formula:
C8H8Cl2N4
Calculated chemical properties:
MW 232.09
NB_atoms 14
XLogP -0.01
PSA 69.099
NB_HD 5
NB_HA 3
fsp3 0.00
Lipinski(0=no;1=yes) 1
NB_atoms 14
XLogP -0.01
PSA 69.099
NB_HD 5
NB_HA 3
fsp3 0.00
Lipinski(0=no;1=yes) 1
FDA
NDA 018587 (pdf not found) INN (GUANABENZ ACETATE) WYTENSIN (WYETH AYERST) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 074025 (pdf not found) INN (GUANABENZ ACETATE) GUANABENZ ACETATE (WATSON LABS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074267 (pdf not found) INN (GUANABENZ ACETATE) GUANABENZ ACETATE (ANI PHARMS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074149 (pdf not found) INN (GUANABENZ ACETATE) GUANABENZ ACETATE (ANI PHARMS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074517 (label) INN (GUANABENZ ACETATE) GUANABENZ ACETATE (CHARTWELL RX) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 018587 (pdf not found) INN (GUANABENZ ACETATE) WYTENSIN (WYETH AYERST) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 074025 (pdf not found) INN (GUANABENZ ACETATE) GUANABENZ ACETATE (WATSON LABS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074267 (pdf not found) INN (GUANABENZ ACETATE) GUANABENZ ACETATE (ANI PHARMS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074149 (pdf not found) INN (GUANABENZ ACETATE) GUANABENZ ACETATE (ANI PHARMS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074517 (label) INN (GUANABENZ ACETATE) GUANABENZ ACETATE (CHARTWELL RX) APPROVAL= AP YEAR= 1998 DISCONTINUED