e-Drug3D

51

cas 51-52-5

CLASS

HORMONES
TREATMENT OF HYPERTHYROIDISM
INHIBITS THE SYNTHESIS OF THYROID HORMONES

ROUTE (list)

ORAL

PK parameters

Tmax 0.75 HOUR
VD 22.1 LITER (65 KILOGRAM)
Cl 12.09 LITER / HOUR (65 KILOGRAM)
PPB 82 PERCENT
t1/2 1.3 HOUR

TARGET THYROPEROXIDASE (PMID12755690)

PDB
5HPW (MODE OF BINDING OF ANTITHYROID DRUG, PROPYLTHIOURACIL TO LACTOPEROXIDASE: BINDING STUDIES AND STRUCTURE DETERMINATION)

Ligand code = 3CJ (link to the list of PDB complexes)

Download experimental 3D coordinates of 3CJ with added hydrogens

MW 170.24
NB_atoms 11
XLogP 1.38
PSA 43.337
NB_HD 2
NB_HA 3
fsp3 0.43
Lipinski(0=no;1=yes) 1

FDA
NDA 080015 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (HALSEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080215 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (ANI PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080840 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (TABLICAPS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080932 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084075 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (ABBOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084543 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (CHARTWELL RX) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 006188 (label) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (PH HEALTH) APPROVAL= AP YEAR= 1947
NDA 006213 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (LILLY) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 080016 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1970 DISCONTINUED
NDA 080154 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (QUAGEN) APPROVAL= AP YEAR= 1971
NDA 080159 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (IMPAX LABS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080172 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 1973
NDA 080285 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (ANABOLIC) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 083982 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 085201 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 208867 (pdf not found) INN (PROPYLTHIOURACIL) PROPYLTHIOURACIL (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2023