e-Drug3D

DESOXYCORTICOSTERONE ACETATE

DISCONTINUED

INN
DESOXYCORTICOSTERONE ACETATE

(has an active metabolite)

cas 56-47-3

CLASS

HORMONES
ADRENOCORTICAL STEROID
PRECURSOR OF ALDOSTERONE
SUBSTRATE OF ALDOSTERONE SYNTHASE (CYTOCHROME P450 CYP11B2)

ROUTE (list)

INJECTION IMPLANTATION

ATC code

H02AA03

PK parameters

Target

TARGET ALDOSTERONE SYNTHASE

PDB
4DVQ (HUMAN ALDOSTERONE SYNTHASE PMID23322723)

Ligand code = - (link to the list of PDB complexes)

Download experimental 3D coordinates of - with added hydrogens

DrugCentral

Mineralocorticoid receptor UNIPROT P08235 NR3C2

Download SDF file

[2-[(8S,9S,10R,13S,14S,17S)-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate

Formula:
C23H32O4

Calculated chemical properties:

MW 372.49
NB_atoms 27
XLogP 4.27
PSA 59.35
NB_HD 0
NB_HA 4
fsp3 0.78
Lipinski(0=no;1=yes) 1

FDA
NDA 001104 (pdf not found) INN (DESOXYCORTICOSTERONE ACETATE) DOCA (ORGANON USA INC) APPROVAL= AP YEAR= 1939 DISCONTINUED
NDA 005151 (pdf not found) INN (DESOXYCORTICOSTERONE ACETATE) PERCORTEN (NOVARTIS) APPROVAL= AP YEAR= 1942 DISCONTINUED