e-Drug3D

486

GUANADREL

DISCONTINUED

INN
GUANADREL

cas 40580-59-4

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ADRENERGIC NEURON BLOCKER

ROUTE (list)

ORAL

ATC code

PK parameters

Tmax 1.75 HOUR
VD 747 LITER (65 KILOGRAM)
Cl 162 LITER / HOUR
t1/2 3.7 HOUR (PMID2715368)

Target

DrugCentral

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

2-(1,4-dioxaspiro[4.5]decan-2-ylmethyl)guanidine

Formula:
C10H19N3O2

Calculated chemical properties:

MW 213.28
NB_atoms 15
XLogP 0.34
PSA 78.019
NB_HD 4
NB_HA 5
fsp3 0.90
Lipinski(0=no;1=yes) 1

FDA
NDA 018104 (pdf not found) INN (GUANADREL SULFATE) HYLOREL (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1982 NEWMOLECULARENTITY DISCONTINUED