e-Drug3D
477
TIMOLOL
INN
TIMOLOL
cas 26839-75-8
CLASS
CARDIOVASCULAR
NON-SELECTIVE BETA ADRENERGIC BLOCKER
ANTI-ARRHYTHMIA AGENTS
ANTIHYPERTENSIVE AGENTS
ANTIMIGRAINE
ANTIGLAUCOMA
ANTIANGINAL
ROUTE (list)
ORAL OPHTHALMIC
PK parameters
Cmax 1.45 NANOMOLAR
VD 97.5 LITER (65 KILOGRAM)
Cl 33.1 LITER / HOUR (65 KILOGRAM)
PPB 10 PERCENT
t1/2 2.2 HOUR
Solubility
SOLUBLE IN WATER
TARGET BETA-1 ADRENERGIC RECEPTOR
BETA-2 ADRENERGIC RECEPTOR
BETA-2 ADRENERGIC RECEPTOR
PDB
3D4S (CHOLESTEROL BOUND FORM OF HUMAN BETA2 ADRENERGIC RECEPTOR.)
Ligand code = TIM (link to the list of PDB complexes)
Download experimental 3D coordinates of TIM with added hydrogens
Beta-1 adrenergic receptor UNIPROT P08588 ADRB1
Beta-2 adrenergic receptor UNIPROT P07550 ADRB2
Formula:
C13H24N4O3S
Calculated chemical properties:
MW 316.43
NB_atoms 21
XLogP 0.50
PSA 81.949
NB_HD 2
NB_HA 7
fsp3 0.85
Lipinski(0=no;1=yes) 1
NB_atoms 21
XLogP 0.50
PSA 81.949
NB_HD 2
NB_HA 7
fsp3 0.85
Lipinski(0=no;1=yes) 1
FDA
NDA 072001 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072002 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072003 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072269 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072270 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072271 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072466 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072467 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072468 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018086 (label) INN (TIMOLOL MALEATE) TIMOPTIC (BAUSCH AND LOMB INC) APPROVAL= AP YEAR= 1978
NDA 018017 (pdf not found) INN (TIMOLOL MALEATE) BLOCADREN (MERCK) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 018061 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TIMOLOL MALEATE) TIMOLIDE 10-25 (MERCK) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 019463 (label) INN (TIMOLOL MALEATE) TIMOPTIC IN OCUDOSE (BAUSCH AND LOMB INC) APPROVAL= AP YEAR= 1986
NDA 072550 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (CHARTWELL RX) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072551 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (CHARTWELL RX) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072552 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (CHARTWELL RX) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072668 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (MYLAN) APPROVAL= AP YEAR= 1990
NDA 072917 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (ANI PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072918 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (ANI PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072919 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (ANI PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 020330 (label) INN (TIMOLOL MALEATE) TIMOPTIC-XE (BAUSCH AND LOMB INC) APPROVAL= AP YEAR= 1993
NDA 072648 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (TEVA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 072649 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (TEVA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 072650 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (TEVA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020439 (label) INN (TIMOLOL) BETIMOL (THEA PHARMA) APPROVAL= AP YEAR= 1995
NDA 074261 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 1995
NDA 074262 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 1995
NDA 074465 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074466 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074515 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074516 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074667 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (FOUGERA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074668 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (FOUGERA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074746 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (PACIFIC PHARMA) APPROVAL= AP YEAR= 1997
NDA 074747 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (PACIFIC PHARMA) APPROVAL= AP YEAR= 1997
NDA 074776 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074778 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 020869 (label) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) COSOPT (THEA PHARMA) APPROVAL= AP YEAR= 1998
NDA 020963 (label) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 1998
NDA 075411 (label) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (APOTEX INC) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075412 (label) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (APOTEX INC) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075163 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (HIKMA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021516 (label) INN (TIMOLOL MALEATE) ISTALOL (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2004
NDA 021398 (label) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) COMBIGAN (ABBVIE) APPROVAL= AP YEAR= 2007
NDA 077259 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (FDC LTD) APPROVAL= AP YEAR= 2008
NDA 077847 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (HIKMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078201 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078749 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 2008
NDA 078704 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (TEVA PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 078771 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (MANKIND PHARMA) APPROVAL= AP YEAR= 2009
NDA 090037 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2009
NDA 090604 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 091574 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE; TIMOLOL MALEATE (ALCON) APPROVAL= TA YEAR= 2010
NDA 202667 (label) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) COSOPT PF (THEA PHARMA) APPROVAL= AP YEAR= 2012
NDA 091180 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (ZAMBON SPA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 201998 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202054 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (REGCON HOLDINGS) APPROVAL= AP YEAR= 2014
NDA 203058 (label) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2014
NDA 204936 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (APOTEX) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 204912 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (AKORN INC) APPROVAL= TA YEAR= 2015
NDA 205309 (pdf not found) INN (TIMOLOL) TIMOLOL (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 207630 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2018
NDA 207556 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (RISING) APPROVAL= AP YEAR= 2019
NDA 205295 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (FDC LTD) APPROVAL= AP YEAR= 2019
NDA 207523 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (SOMERSET) APPROVAL= AP YEAR= 2019
NDA 204777 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (MICRO LABS) APPROVAL= AP YEAR= 2020
NDA 212291 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2020
NDA 212942 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (ALEMBIC) APPROVAL= AP YEAR= 2020
NDA 207629 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2021
NDA 213099 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (ALEMBIC) APPROVAL= AP YEAR= 2021
NDA 212592 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (J MOLNER) APPROVAL= AP YEAR= 2021
NDA 091086 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (SENTISS) APPROVAL= AP YEAR= 2022
NDA 091087 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 2022
NDA 091442 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (APOTEX) APPROVAL= AP YEAR= 2022
NDA 214645 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (GLAND) APPROVAL= AP YEAR= 2022
NDA 215936 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (MICRO LABS) APPROVAL= AP YEAR= 2022
NDA 201949 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (REGCON HOLDINGS) APPROVAL= AP YEAR= 2022
NDA 215520 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (GLAND) APPROVAL= AP YEAR= 2022
NDA 215598 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2022
NDA 215733 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (DR REDDYS) APPROVAL= AP YEAR= 2022
NDA 216533 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2022
NDA 216596 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (MICRO LABS) APPROVAL= AP YEAR= 2022
NDA 213540 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2023
NDA 217195 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SENTISS PHARMA) APPROVAL= AP YEAR= 2023
NDA 217260 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2023
NDA 217343 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (MICRO LABS) APPROVAL= AP YEAR= 2023
NDA 215230 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (ALEMBIC) APPROVAL= AP YEAR= 2023
NDA 214987 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2024
NDA 216343 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (AMNEAL) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 210640 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024
NDA 216114 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (SOMERSET) APPROVAL= AP YEAR= 2024
NDA 216653 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024
NDA 216654 (pdf not found) INN (TIMOLOL) TIMOLOL (SOMERSET) APPROVAL= AP YEAR= 2024
NDA 217288 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (AMNEAL) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 217764 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SOMERSET) APPROVAL= AP YEAR= 2024
NDA 218460 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (CAPLIN) APPROVAL= AP YEAR= 2024
NDA 216308 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (ALEMBIC THERAP) APPROVAL= AP YEAR= 2025
NDA 219093 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (CAPLIN) APPROVAL= AP YEAR= 2025
NDA 217934 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (SABA ILAC SANAYIVE) APPROVAL= AP YEAR= 2026
NDA 219166 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (GLAND) APPROVAL= AP YEAR= 2026
NDA 072001 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072002 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072003 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072269 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072270 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072271 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072466 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072467 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072468 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (QUANTUM PHARMICS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 018086 (label) INN (TIMOLOL MALEATE) TIMOPTIC (BAUSCH AND LOMB INC) APPROVAL= AP YEAR= 1978
NDA 018017 (pdf not found) INN (TIMOLOL MALEATE) BLOCADREN (MERCK) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 018061 (pdf not found) INN (HYDROCHLOROTHIAZIDE ; TIMOLOL MALEATE) TIMOLIDE 10-25 (MERCK) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 019463 (label) INN (TIMOLOL MALEATE) TIMOPTIC IN OCUDOSE (BAUSCH AND LOMB INC) APPROVAL= AP YEAR= 1986
NDA 072550 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (CHARTWELL RX) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072551 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (CHARTWELL RX) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072552 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (CHARTWELL RX) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 072668 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (MYLAN) APPROVAL= AP YEAR= 1990
NDA 072917 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (ANI PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072918 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (ANI PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072919 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (ANI PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 020330 (label) INN (TIMOLOL MALEATE) TIMOPTIC-XE (BAUSCH AND LOMB INC) APPROVAL= AP YEAR= 1993
NDA 072648 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (TEVA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 072649 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (TEVA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 072650 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (TEVA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020439 (label) INN (TIMOLOL) BETIMOL (THEA PHARMA) APPROVAL= AP YEAR= 1995
NDA 074261 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 1995
NDA 074262 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 1995
NDA 074465 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074466 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074515 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074516 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074667 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (FOUGERA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074668 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (FOUGERA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074746 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (PACIFIC PHARMA) APPROVAL= AP YEAR= 1997
NDA 074747 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (PACIFIC PHARMA) APPROVAL= AP YEAR= 1997
NDA 074776 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074778 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 020869 (label) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) COSOPT (THEA PHARMA) APPROVAL= AP YEAR= 1998
NDA 020963 (label) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 1998
NDA 075411 (label) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (APOTEX INC) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075412 (label) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (APOTEX INC) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075163 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (HIKMA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021516 (label) INN (TIMOLOL MALEATE) ISTALOL (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2004
NDA 021398 (label) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) COMBIGAN (ABBVIE) APPROVAL= AP YEAR= 2007
NDA 077259 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (FDC LTD) APPROVAL= AP YEAR= 2008
NDA 077847 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (HIKMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078201 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078749 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 2008
NDA 078704 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (TEVA PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 078771 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (MANKIND PHARMA) APPROVAL= AP YEAR= 2009
NDA 090037 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2009
NDA 090604 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 091574 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE; TIMOLOL MALEATE (ALCON) APPROVAL= TA YEAR= 2010
NDA 202667 (label) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) COSOPT PF (THEA PHARMA) APPROVAL= AP YEAR= 2012
NDA 091180 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (ZAMBON SPA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 201998 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202054 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (REGCON HOLDINGS) APPROVAL= AP YEAR= 2014
NDA 203058 (label) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2014
NDA 204936 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (APOTEX) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 204912 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (AKORN INC) APPROVAL= TA YEAR= 2015
NDA 205309 (pdf not found) INN (TIMOLOL) TIMOLOL (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 207630 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2018
NDA 207556 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (RISING) APPROVAL= AP YEAR= 2019
NDA 205295 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (FDC LTD) APPROVAL= AP YEAR= 2019
NDA 207523 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (SOMERSET) APPROVAL= AP YEAR= 2019
NDA 204777 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (MICRO LABS) APPROVAL= AP YEAR= 2020
NDA 212291 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2020
NDA 212942 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (ALEMBIC) APPROVAL= AP YEAR= 2020
NDA 207629 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2021
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NDA 212592 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (J MOLNER) APPROVAL= AP YEAR= 2021
NDA 091086 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (SENTISS) APPROVAL= AP YEAR= 2022
NDA 091087 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 2022
NDA 091442 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (APOTEX) APPROVAL= AP YEAR= 2022
NDA 214645 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (GLAND) APPROVAL= AP YEAR= 2022
NDA 215936 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (MICRO LABS) APPROVAL= AP YEAR= 2022
NDA 201949 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (REGCON HOLDINGS) APPROVAL= AP YEAR= 2022
NDA 215520 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (GLAND) APPROVAL= AP YEAR= 2022
NDA 215598 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2022
NDA 215733 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (DR REDDYS) APPROVAL= AP YEAR= 2022
NDA 216533 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2022
NDA 216596 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (MICRO LABS) APPROVAL= AP YEAR= 2022
NDA 213540 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2023
NDA 217195 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SENTISS PHARMA) APPROVAL= AP YEAR= 2023
NDA 217260 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2023
NDA 217343 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (MICRO LABS) APPROVAL= AP YEAR= 2023
NDA 215230 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (ALEMBIC) APPROVAL= AP YEAR= 2023
NDA 214987 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2024
NDA 216343 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (AMNEAL) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 210640 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024
NDA 216114 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (SOMERSET) APPROVAL= AP YEAR= 2024
NDA 216653 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2024
NDA 216654 (pdf not found) INN (TIMOLOL) TIMOLOL (SOMERSET) APPROVAL= AP YEAR= 2024
NDA 217288 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (AMNEAL) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 217764 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (SOMERSET) APPROVAL= AP YEAR= 2024
NDA 218460 (pdf not found) INN (TIMOLOL MALEATE) TIMOLOL MALEATE (CAPLIN) APPROVAL= AP YEAR= 2024
NDA 216308 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (ALEMBIC THERAP) APPROVAL= AP YEAR= 2025
NDA 219093 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (CAPLIN) APPROVAL= AP YEAR= 2025
NDA 217934 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (SABA ILAC SANAYIVE) APPROVAL= AP YEAR= 2026
NDA 219166 (pdf not found) INN (BRIMONIDINE TARTRATE ; TIMOLOL MALEATE) BRIMONIDINE TARTRATE AND TIMOLOL MALEATE (GLAND) APPROVAL= AP YEAR= 2026