e-Drug3D

470

BROMOCRIPTINE

INN
BROMOCRIPTINE

cas 25614-03-3

CLASS

NERVOUS SYSTEM
ANTIPARKINSONIAN
ANTIDYSKINETICS
DOPAMINE AGONISTS
ERGOT DERIVATIVE
SIGNIFICANTLY REDUCES PLASMA LEVELS OF PROLACTIN

ROUTE (list)

ORAL

ATC code

G02CB01
N04BC01

PK parameters

F 80 PERCENT
Tmax 2.5 HOUR
VD 61 LITER
Cl 7 LITER / HOUR (EQN)
PPB 93 PERCENT
t1/2 6 HOUR

Target

TARGET D(2) DOPAMINE RECEPTOR

PDB
5VCG (CRYSTAL STRUCTURE OF THE CYSTEINE DEPLETED CYP3A4 BOUND TO BROMOERGOCRYPTINE)

Ligand code = 08Y (link to the list of PDB complexes)

Download experimental 3D coordinates of 08Y with added hydrogens

DrugCentral

D(2) dopamine receptor UNIPROT P14416 DRD2

Download SDF file

Ergotaman-3',6',18-trione, 2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)-, (5'.alpha.)-

Formula:
C32H40BrN5O5

Calculated chemical properties:

MW 654.59
NB_atoms 43
XLogP 3.19
PSA 104.216
NB_HD 3
NB_HA 10
fsp3 0.59
Lipinski(0=no;1=yes) 0

FDA
NDA 017962 (label) INN (BROMOCRIPTINE MESYLATE) PARLODEL (ESJAY PHARMA) APPROVAL= AP YEAR= 1978
NDA 074631 (pdf not found) INN (BROMOCRIPTINE MESYLATE) BROMOCRIPTINE MESYLATE (SANDOZ) APPROVAL= AP YEAR= 1998
NDA 075100 (pdf not found) INN (BROMOCRIPTINE MESYLATE) BROMOCRIPTINE MESYLATE (LEK PHARM) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 076962 (pdf not found) INN (BROMOCRIPTINE MESYLATE) BROMOCRIPTINE MESYLATE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077226 (pdf not found) INN (BROMOCRIPTINE MESYLATE) BROMOCRIPTINE MESYLATE (MYLAN) APPROVAL= AP YEAR= 2005
NDA 078899 (pdf not found) INN (BROMOCRIPTINE MESYLATE) BROMOCRIPTINE MESYLATE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2008
NDA 077646 (pdf not found) INN (BROMOCRIPTINE MESYLATE) BROMOCRIPTINE MESYLATE (PADAGIS US) APPROVAL= AP YEAR= 2008
NDA 020866 (label) INN (BROMOCRIPTINE MESYLATE) CYCLOSET (VEROSCIENCE) APPROVAL= AP YEAR= 2009