e-Drug3D
468
cas 38194-50-2
CLASS
MUSCULO-SKELETAL
ANTIINFLAMMATORY
NSAID
CYCLOOXYGENASE INHIBITORS
ROUTE (list)
ORAL
ATC code
M01AB02
PK parameters
F 90 PERCENT
Tmax 2.5 HOUR
VD 170.2 LITER
Cl 20.2 LITER / HOUR
PPB 93.1 PERCENT
t1/2 7.28 HOUR
Solubility
VERY SOLUBLE AS THE SODIUM SALT OR IN BUFFERS OF PH 6 OR HIGHER
TARGET PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2
PROSTAGLANDIN G/H SYNTHASE 2
PDB
2KAW (NMR STRUCTURE OF THE MDVL1 PDZ DOMAIN IN COMPLEX WITH ITS INHIBITOR)
Ligand code = SUZ (link to the list of PDB complexes)
Download experimental 3D coordinates of SUZ with added hydrogens
Prostaglandin G,H synthase 2 UNIPROT P35354 PTGS2
Formula:
C20H17FO3S
Calculated chemical properties:
MW 355.40
NB_atoms 25
XLogP 3.03
PSA 52.132
NB_HD 0
NB_HA 3
fsp3 0.15
Lipinski(0=no;1=yes) 1
NB_atoms 25
XLogP 3.03
PSA 52.132
NB_HD 0
NB_HA 3
fsp3 0.15
Lipinski(0=no;1=yes) 1
FDA
NDA 017911 (label) INN (SULINDAC) CLINORIL (MERCK) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 071795 (pdf not found) INN (SULINDAC) SULINDAC (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 071891 (pdf not found) INN (SULINDAC) SULINDAC (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 072050 (pdf not found) INN (SULINDAC) SULINDAC (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1991
NDA 072051 (pdf not found) INN (SULINDAC) SULINDAC (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1991
NDA 072710 (pdf not found) INN (SULINDAC) SULINDAC (EPIC PHARMA) APPROVAL= AP YEAR= 1991 OBSOLETE
NDA 072711 (pdf not found) INN (SULINDAC) SULINDAC (EPIC PHARMA) APPROVAL= AP YEAR= 1991
NDA 072712 (pdf not found) INN (SULINDAC) SULINDAC (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072713 (pdf not found) INN (SULINDAC) SULINDAC (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073261 (pdf not found) INN (SULINDAC) SULINDAC (RADIUS PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073262 (pdf not found) INN (SULINDAC) SULINDAC (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072972 (pdf not found) INN (SULINDAC) SULINDAC (ANI PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED OBSOLETE
NDA 072973 (pdf not found) INN (SULINDAC) SULINDAC (ANI PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073038 (pdf not found) INN (SULINDAC) SULINDAC (MYLAN) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 073039 (pdf not found) INN (SULINDAC) SULINDAC (RISING) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 017911 (label) INN (SULINDAC) CLINORIL (MERCK) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 071795 (pdf not found) INN (SULINDAC) SULINDAC (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 071891 (pdf not found) INN (SULINDAC) SULINDAC (WATSON LABS) APPROVAL= AP YEAR= 1988
NDA 072050 (pdf not found) INN (SULINDAC) SULINDAC (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1991
NDA 072051 (pdf not found) INN (SULINDAC) SULINDAC (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1991
NDA 072710 (pdf not found) INN (SULINDAC) SULINDAC (EPIC PHARMA) APPROVAL= AP YEAR= 1991 OBSOLETE
NDA 072711 (pdf not found) INN (SULINDAC) SULINDAC (EPIC PHARMA) APPROVAL= AP YEAR= 1991
NDA 072712 (pdf not found) INN (SULINDAC) SULINDAC (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072713 (pdf not found) INN (SULINDAC) SULINDAC (CHARTWELL RX) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073261 (pdf not found) INN (SULINDAC) SULINDAC (RADIUS PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 073262 (pdf not found) INN (SULINDAC) SULINDAC (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072972 (pdf not found) INN (SULINDAC) SULINDAC (ANI PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED OBSOLETE
NDA 072973 (pdf not found) INN (SULINDAC) SULINDAC (ANI PHARMS) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073038 (pdf not found) INN (SULINDAC) SULINDAC (MYLAN) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 073039 (pdf not found) INN (SULINDAC) SULINDAC (RISING) APPROVAL= AP YEAR= 1993 DISCONTINUED