e-Drug3D

449

cas 4618-18-2

CLASS

METABOLISM
SYNTHETIC DISACCHARIDE
A COLONIC ACIDIFIER FOR TREATMENT AND PREVENTION OF PORTAL-SYSTEMIC ENCEPHALOPATHY
REDUCES THE BLOOD AMMONIA LEVELS

ROUTE (list)

ORAL RECTAL

PK parameters

TARGET EVOLVED BETA-GALACTOSIDASE SUBUNIT ALPHA

PDB
3W9T (PORE-FORMING CEL-III)

Ligand code = W9T (link to the list of PDB complexes)

Download experimental 3D coordinates of W9T with added hydrogens

MW 342.30
NB_atoms 23
XLogP -5.40
PSA 194.775
NB_HD 8
NB_HA 11
fsp3 1.00
Lipinski(0=no;1=yes) 0

FDA
NDA 017906 (pdf not found) INN (LACTULOSE) LACTULOSE (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071841 (pdf not found) INN (LACTULOSE) LACTULOSE (MORTON GROVE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071842 (pdf not found) INN (LACTULOSE) GENERLAC (MORTON GROVE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072029 (pdf not found) INN (LACTULOSE) LACTULOSE (PACO) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072372 (pdf not found) INN (LACTULOSE) DUPHALAC (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 072374 (pdf not found) INN (LACTULOSE) PORTALAC (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 073160 (pdf not found) INN (LACTULOSE) LACTULOSE (PACO) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017657 (pdf not found) INN (LACTULOSE) CEPHULAC (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 017884 (pdf not found) INN (LACTULOSE) CHRONULAC (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 070288 (pdf not found) INN (LACTULOSE) CONSTULOSE (ACTAVIS MID ATLANTIC) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071054 (pdf not found) INN (LACTULOSE) CONSTILAC (ALRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071331 (pdf not found) INN (LACTULOSE) CHOLAC (ALRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071548 (pdf not found) INN (LACTULOSE) ENULOSE (ACTAVIS MID ATLANTIC) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 073590 (pdf not found) INN (LACTULOSE) LACTULOSE (ROXANE) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073591 (pdf not found) INN (LACTULOSE) LACTULOSE (HIKMA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 074138 (pdf not found) INN (LACTULOSE) LACTULOSE (VISTAPHARM LLC) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073497 (pdf not found) INN (LACTULOSE) EVALOSE (TEVA PHARMS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 073504 (pdf not found) INN (LACTULOSE) HEPTALAC (TEVA PHARMS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 073685 (pdf not found) INN (LACTULOSE) ACILAC (NOSTRUM LABS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 073686 (pdf not found) INN (LACTULOSE) LAXILOSE (NOSTRUM LABS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074076 (pdf not found) INN (LACTULOSE) LACTULOSE (HIKMA) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074077 (pdf not found) INN (LACTULOSE) LACTULOSE (PAI HOLDINGS PHARM) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074602 (pdf not found) INN (LACTULOSE) LACTULOSE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 1996
NDA 074603 (pdf not found) INN (LACTULOSE) GENERLAC (CHARTWELL RX) APPROVAL= AP YEAR= 1996
NDA 074623 (pdf not found) INN (LACTULOSE) LACTULOSE (PHARM ASSOC) APPROVAL= AP YEAR= 1996
NDA 074712 (pdf not found) INN (LACTULOSE) LACTULOSE (CUMBERLAND PHARMS) APPROVAL= AP YEAR= 1997
NDA 075993 (pdf not found) INN (LACTULOSE) LACTULOSE (LANNETT CO INC) APPROVAL= AP YEAR= 2001
NDA 075911 (pdf not found) INN (LACTULOSE) LACTULOSE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2002
NDA 076645 (pdf not found) INN (LACTULOSE) LACTULOSE (BAJAJ) APPROVAL= AP YEAR= 2003
NDA 078430 (pdf not found) INN (LACTULOSE) LACTULOSE (ANI PHARMS) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 090426 (pdf not found) INN (LACTULOSE) LACTULOSE (ANI PHARMS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 090502 (pdf not found) INN (LACTULOSE) LACTULOSE (FRESENIUS KABI) APPROVAL= AP YEAR= 2012
NDA 090503 (pdf not found) INN (LACTULOSE) LACTULOSE (FRESENIUS KABI) APPROVAL= AP YEAR= 2012
NDA 203762 (pdf not found) INN (LACTULOSE) LACTULOSE (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2015
NDA 207786 (pdf not found) INN (LACTULOSE) LACTULOSE (APOZEAL PHARMS) APPROVAL= AP YEAR= 2018
NDA 209517 (pdf not found) INN (LACTULOSE) LACTULOSE (CHARTWELL RX) APPROVAL= AP YEAR= 2018
NDA 218858 (pdf not found) INN (LACTULOSE) LACTULOSE (TARO) APPROVAL= AP YEAR= 2024
NDA 217914 (pdf not found) INN (LACTULOSE) LACTULOSE (PAI HOLDINGS) APPROVAL= AP YEAR= 2025