e-Drug3D

44

cas 83919-23-7

CLASS

METABOLISM
ANTI-ALLERGIC AGENTS
ANTI-INFLAMMATORY AGENTS

ROUTE (list)

TOPICAL NASAL INHALATION IMPLANTATION

PK parameters

Tmax 1.75 HOUR
VD 152 LITER
Cl 48.7 LITER / HOUR (65 KILOGRAM)
PPB 98.5 PERCENT
t1/2 5.8 HOUR

TARGET GLUCOCORTICOID RECEPTOR

PDB
4P6W (CRYSTAL STRUCTURE OF MOMETASONE FUROATE-BOUND GLUCOCORTICOID RECEPTOR LIGAND BINDING DOMAIN)

Ligand code = MOF (link to the list of PDB complexes)

Download experimental 3D coordinates of MOF with added hydrogens

MW 521.41
NB_atoms 35
XLogP 4.87
PSA 75.333
NB_HD 1
NB_HA 6
fsp3 0.59
Lipinski(0=no;1=yes) 0

FDA
NDA 019543 (label) INN (MOMETASONE FUROATE) ELOCON (ORGANON) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 019625 (label) INN (MOMETASONE FUROATE) ELOCON (ORGANON) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 019796 (label) INN (MOMETASONE FUROATE) ELOCON (ORGANON) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 020762 (label) INN (MOMETASONE FUROATE) NASONEX (ORGANON LLC) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 076067 (label) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (PADAGIS US) APPROVAL= AP YEAR= 2002
NDA 076481 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (ENCUBE) APPROVAL= AP YEAR= 2003
NDA 076624 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (SUN PHARMA CANADA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076679 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (SUN PHARMA CANADA) APPROVAL= AP YEAR= 2004
NDA 021067 (label) INN (MOMETASONE FUROATE) ASMANEX TWISTHALER (ORGANON LLC) APPROVAL= AP YEAR= 2005
NDA 076171 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (FOUGERA PHARMS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077061 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (FOUGERA PHARMS) APPROVAL= AP YEAR= 2005
NDA 077180 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2005
NDA 076788 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (SUN PHARMA CANADA) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077401 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 2006
NDA 077447 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 2006
NDA 075919 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (FOUGERA PHARMS) APPROVAL= AP YEAR= 2007
NDA 076499 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (ENCUBE) APPROVAL= AP YEAR= 2007
NDA 076591 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077678 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078541 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (GLENMARK PHARMS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078571 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (GLENMARK PHARMS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 022518 (label) INN (FORMOTEROL FUMARATE ; MOMETASONE FUROATE) DULERA (ORGANON LLC) APPROVAL= AP YEAR= 2010
NDA 090506 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 205641 (label) INN (MOMETASONE FUROATE) ASMANEX HFA (ORGANON LLC) APPROVAL= AP YEAR= 2014
NDA 091161 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (APOTEX) APPROVAL= AP YEAR= 2016
NDA 207989 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2017
NDA 209310 (label) INN (MOMETASONE FUROATE) SINUVA (INTERSECT ENT INC) APPROVAL= AP YEAR= 2017
NDA 207899 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (TORRENT) APPROVAL= AP YEAR= 2018
NDA 211746 (label) INN (MOMETASONE FUROATE ; OLOPATADINE HYDROCHLORIDE) RYALTRIS (GLENMARK SPECLT) APPROVAL= AP YEAR= 2022
NDA 215712 (label) INN (MOMETASONE FUROATE) NASONEX 24HR ALLERGY (PERRIGO PHARMA INTL) APPROVAL= AP YEAR= 2022
NDA 217460 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (AMNEAL) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 215878 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2024
NDA 217438 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (APOTEX) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 217498 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 211706 (pdf not found) INN (MOMETASONE FUROATE) MOMETASONE FUROATE (NASPRESS) APPROVAL= AP YEAR= 2025 DISCONTINUED