e-Drug3D

417

cas 92-13-7

CLASS

NERVOUS SYSTEM
CHOLINERGIC
ANTIGLAUCOMA
MIOTICS
MUSCARINIC AGONISTS

ROUTE (list)

OPHTHALMIC ORAL

PK parameters

Tmax 0.85 HOUR
PPB 0 PERCENT
t1/2 1.35 HOUR

TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR M1
MUSCARINIC ACETYLCHOLINE RECEPTOR M2

PDB
3T3R (HUMAN CYTOCHROME P450 2A6 IN COMPLEX WITH PILOCARPINE)

Ligand code = 9PL (link to the list of PDB complexes)

Download experimental 3D coordinates of 9PL with added hydrogens

MW 208.26
NB_atoms 15
XLogP 1.16
PSA 42.829
NB_HD 0
NB_HA 4
fsp3 0.64
Lipinski(0=no;1=yes) 1

FDA
NDA 017431 (pdf not found) INN (PILOCARPINE) OCUSERT PILO-20 (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 017548 (pdf not found) INN (PILOCARPINE) OCUSERT PILO-40 (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 018796 (label) INN (PILOCARPINE HYDROCHLORIDE) PILOPINE HS (ALCON) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 020237 (label) INN (PILOCARPINE HYDROCHLORIDE) SALAGEN (ADVANZ PHARMA) APPROVAL= AP YEAR= 1994
NDA 020619 (pdf not found) INN (BETAXOLOL HYDROCHLORIDE ; PILOCARPINE HYDROCHLORIDE) BETOPTIC PILO (ALCON) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 076746 (pdf not found) INN (PILOCARPINE HYDROCHLORIDE) PILOCARPINE HYDROCHLORIDE (PADAGIS US) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076963 (pdf not found) INN (PILOCARPINE HYDROCHLORIDE) PILOCARPINE HYDROCHLORIDE (INNOGENIX) APPROVAL= AP YEAR= 2004
NDA 077220 (pdf not found) INN (PILOCARPINE HYDROCHLORIDE) PILOCARPINE HYDROCHLORIDE (LANNETT CO INC) APPROVAL= AP YEAR= 2005
NDA 077248 (pdf not found) INN (PILOCARPINE HYDROCHLORIDE) PILOCARPINE HYDROCHLORIDE (IMPAX LABS) APPROVAL= AP YEAR= 2006
NDA 200890 (label) INN (PILOCARPINE HYDROCHLORIDE) ISOPTO CARPINE (SANDOZ) APPROVAL= AP YEAR= 2010
NDA 204398 (pdf not found) INN (PILOCARPINE HYDROCHLORIDE) PILOCARPINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2017
NDA 210384 (pdf not found) INN (PILOCARPINE HYDROCHLORIDE) PILOCARPINE HYDROCHLORIDE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2019
NDA 212377 (pdf not found) INN (PILOCARPINE HYDROCHLORIDE) PILOCARPINE HYDROCHLORIDE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2019
NDA 214193 (pdf not found) INN (PILOCARPINE HYDROCHLORIDE) PILOCARPINE HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2020
NDA 214028 (label) INN (PILOCARPINE HYDROCHLORIDE) VUITY (ABBVIE) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 217836 (label) INN (PILOCARPINE HYDROCHLORIDE) QLOSI (ORASIS PHARMS) APPROVAL= AP YEAR= 2023
NDA 217733 (pdf not found) INN (PILOCARPINE HYDROCHLORIDE) PILOCARPINE HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2025
NDA 217052 (pdf not found) INN (PILOCARPINE HYDROCHLORIDE) PILOCARPINE HYDROCHLORIDE (FDC LTD) APPROVAL= AP YEAR= 2025 DISCONTINUED