e-Drug3D

370

cas 127-07-1

CLASS

ANTINEOPLASTIC
ANTISICKLING AGENTS (SICKLE CELL DISEASE)
NUCLEIC ACID SYNTHESIS INHIBITORS
INHIBITION OF DNA SYNTHESIS BY ACTING AS A RIBONUCLEOTIDE REDUCTASE INHIBITOR

ROUTE (list)

ORAL

PK parameters

Tmax 2.5 HOUR
VD 40 LITER
Cl 5.8 LITER / HOUR (65 KILOGRAM)
PPB 0 PERCENT
t1/2 3.4 HOUR

TARGET RIBONUCLEOSIDE REDUCTASE

PDB
3UB9 (PERIPLASMIC PORTION OF THE HELICOBACTER PYLORI CHEMORECEPTOR TLPB WITH HYDROXYUREA BOUND)

Ligand code = NHY (link to the list of PDB complexes)

Download experimental 3D coordinates of NHY with added hydrogens

MW 76.06
NB_atoms 5
XLogP -0.96
PSA 78.73
NB_HD 4
NB_HA 4
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 016295 (label) INN (HYDROXYUREA) HYDREA (WAYLIS THERAP) APPROVAL= AP YEAR= 1967
NDA 074476 (pdf not found) INN (HYDROXYUREA) HYDROXYUREA (ROXANE) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 075020 (pdf not found) INN (HYDROXYUREA) HYDROXYUREA (BARR LABS INC) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 075143 (pdf not found) INN (HYDROXYUREA) HYDROXYUREA (BARR) APPROVAL= AP YEAR= 1998
NDA 075340 (pdf not found) INN (HYDROXYUREA) HYDROXYUREA (PH HEALTH) APPROVAL= AP YEAR= 1999
NDA 075734 (pdf not found) INN (HYDROXYUREA) HYDROXYUREA (BARR) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 208843 (label) INN (HYDROXYUREA) SIKLOS (THERAVIA) APPROVAL= AP YEAR= 2017
NDA 213438 (pdf not found) INN (HYDROXYUREA) HYDROXYUREA (LEADING) APPROVAL= AP YEAR= 2020
NDA 216593 (label) INN (HYDROXYUREA) XROMI (NOVA LABS LTD) APPROVAL= AP YEAR= 2024
NDA 218021 (pdf not found) INN (HYDROXYUREA) HYDROXYUREA (QILU) APPROVAL= AP YEAR= 2024