e-Drug3D

353

cas 768-94-5

CLASS

NERVOUS SYSTEM
ANTIVIRAL
ANTIPARKINSONIAN
TREATMENT OF DRUG-INDUCED EXTRAPYRIMIDAL REACTIONS

ROUTE (list)

ORAL

PK parameters

Tmax 3.3 HOUR
VD 357 LITER (65 KILOGRAM)
Cl 18.2 LITER / HOUR (65 KILOGRAM)
PPB 67 PERCENT
t1/2 17 HOUR

TARGET (PUTATIVE) NICOTINIC ACETYLCHOLINE RECEPTOR

PDB
2KQT (SOLID-STATE NMR STRUCTURE OF THE M2 TRANSMEMBRANE PEPTIDE OF THE INFLUENZA A VIRUS IN DMPC LIPID BILAYERS BOUND TO DEUTERATED AMANTADINE)

Ligand code = 308 (link to the list of PDB complexes)

Download experimental 3D coordinates of 308 with added hydrogens

MW 151.25
NB_atoms 11
XLogP 1.91
PSA 24.495
NB_HD 2
NB_HA 1
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 016020 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) SYMMETREL (ENDO PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071000 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) SYMADINE (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071382 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016023 (label) INN (AMANTADINE HYDROCHLORIDE) SYMMETREL (ENDO PHARMS) APPROVAL= AP YEAR= 1968 DISCONTINUED
NDA 017118 (label) INN (AMANTADINE HYDROCHLORIDE) SYMMETREL (ENDO PHARMS) APPROVAL= AP YEAR= 1976 NEWAPPLICATION DISCONTINUED
NDA 018101 (label) INN (AMANTADINE HYDROCHLORIDE) SYMMETREL (ENDO PHARMS) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 070589 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 1987
NDA 071293 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1987
NDA 072655 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (G AND W LABS INC) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 073115 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (TEVA PHARMS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 074028 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1993
NDA 074170 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 1994
NDA 074509 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (PHARM ASSOC) APPROVAL= AP YEAR= 1995
NDA 075060 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 1998
NDA 075819 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (ADAPTIS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076186 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2002
NDA 076352 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077659 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077992 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 078720 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (BIONPHARMA) APPROVAL= AP YEAR= 2008
NDA 208278 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2016
NDA 207570 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 208096 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (WATSON LABS INC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 208107 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (WATSON LABS INC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 207571 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208966 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2017
NDA 209035 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2017
NDA 209047 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2017
NDA 209171 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (HERITAGE PHARMA) APPROVAL= AP YEAR= 2017
NDA 209221 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208944 (label) INN (AMANTADINE HYDROCHLORIDE) GOCOVRI (SUPERNUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 209410 (label) INN (AMANTADINE HYDROCHLORIDE) OSMOLEX ER (SUPERNUS PHARMS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 210403 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 210129 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2020
NDA 210215 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (POM PHARMA) APPROVAL= AP YEAR= 2020
NDA 212044 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2020
NDA 214284 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2020
NDA 214178 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (POM PHARMA) APPROVAL= AP YEAR= 2021
NDA 211354 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2022
NDA 212407 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (ADAPTIS) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 214580 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (HUMANWELL PURACAP) APPROVAL= AP YEAR= 2022
NDA 214897 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (ZYDUS) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 218598 (pdf not found) INN (AMANTADINE HYDROCHLORIDE) AMANTADINE HYDROCHLORIDE (ZHEJIANG JUTAI PHARM) APPROVAL= AP YEAR= 2024