e-Drug3D
352
PROTRIPTYLINE
INN
PROTRIPTYLINE
cas 438-60-8
CLASS
NERVOUS SYSTEM
ANTIDEPRESSANT
POLYPHARMACOLOGY
ROUTE (list)
ORAL
ATC code
N06AA11
PK parameters
Tmax 10 HOUR
Solubility
FREELY SOLUBLE IN WATER
-
Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4
Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2
Formula:
C19H21N
Calculated chemical properties:
MW 263.37
NB_atoms 20
XLogP 4.30
PSA 14.685
NB_HD 1
NB_HA 1
fsp3 0.26
Lipinski(0=no;1=yes) 1
NB_atoms 20
XLogP 4.30
PSA 14.685
NB_HD 1
NB_HA 1
fsp3 0.26
Lipinski(0=no;1=yes) 1
FDA
NDA 016012 (label) INN (PROTRIPTYLINE HYDROCHLORIDE) VIVACTIL (TEVA WOMENS) APPROVAL= AP YEAR= 1967 DISCONTINUED
NDA 073644 (label) INN (PROTRIPTYLINE HYDROCHLORIDE) VIVACTIL (CHARTWELL RX) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 073645 (label) INN (PROTRIPTYLINE HYDROCHLORIDE) VIVACTIL (CHARTWELL RX) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 078913 (pdf not found) INN (PROTRIPTYLINE HYDROCHLORIDE) PROTRIPTYLINE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 090462 (pdf not found) INN (PROTRIPTYLINE HYDROCHLORIDE) PROTRIPTYLINE HYDROCHLORIDE (SIGMAPHARM LABS LLC) APPROVAL= AP YEAR= 2010
NDA 202220 (pdf not found) INN (PROTRIPTYLINE HYDROCHLORIDE) PROTRIPTYLINE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2012
NDA 016012 (label) INN (PROTRIPTYLINE HYDROCHLORIDE) VIVACTIL (TEVA WOMENS) APPROVAL= AP YEAR= 1967 DISCONTINUED
NDA 073644 (label) INN (PROTRIPTYLINE HYDROCHLORIDE) VIVACTIL (CHARTWELL RX) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 073645 (label) INN (PROTRIPTYLINE HYDROCHLORIDE) VIVACTIL (CHARTWELL RX) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 078913 (pdf not found) INN (PROTRIPTYLINE HYDROCHLORIDE) PROTRIPTYLINE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 090462 (pdf not found) INN (PROTRIPTYLINE HYDROCHLORIDE) PROTRIPTYLINE HYDROCHLORIDE (SIGMAPHARM LABS LLC) APPROVAL= AP YEAR= 2010
NDA 202220 (pdf not found) INN (PROTRIPTYLINE HYDROCHLORIDE) PROTRIPTYLINE HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2012