e-Drug3D

346

cas 61-68-7

CLASS

MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY
ANALGESIC
ANTIPYRETIC
PROSTAGLANDIN SYNTHETASE INHIBITION

ROUTE (list)

ORAL

PK parameters

Tmax 2 HOUR
VD 68.9 LITER (65 KILOGRAM)
Cl 21.2 LITER / HOUR
PPB 90 PERCENT
t1/2 3 HOUR

TARGET PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2

PDB
4JQA (AKR1C2 COMPLEX WITH MEFENAMIC ACID)

Ligand code = ID8 (link to the list of PDB complexes)

Download experimental 3D coordinates of ID8 with added hydrogens

MW 240.27
NB_atoms 18
XLogP 2.41
PSA 42.769
NB_HD 1
NB_HA 3
fsp3 0.13
Lipinski(0=no;1=yes) 1

FDA
NDA 015034 (label) INN (MEFENAMIC ACID) PONSTEL (AVION PHARMS) APPROVAL= AP YEAR= 1967
NDA 090562 (pdf not found) INN (MEFENAMIC ACID) MEFENAMIC ACID (MICRO LABS) APPROVAL= AP YEAR= 2010
NDA 091322 (pdf not found) INN (MEFENAMIC ACID) MEFENAMIC ACID (LUPIN LTD) APPROVAL= AP YEAR= 2011
NDA 090359 (pdf not found) INN (MEFENAMIC ACID) MEFENAMIC ACID (MPP PHARMA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 091608 (pdf not found) INN (MEFENAMIC ACID) MEFENAMIC ACID (AJENAT PHARMS) APPROVAL= AP YEAR= 2014
NDA 209209 (pdf not found) INN (MEFENAMIC ACID) MEFENAMIC ACID (CHARTWELL RX) APPROVAL= AP YEAR= 2020 DISCONTINUED