e-Drug3D
3
HISTAMINE
DISCONTINUED
INN
HISTAMINE
cas 51-45-6
CLASS
DIAGNOSTIC AID
HISTAMINE RECEPTOR AGONIST
ACUTE MYELOID LEUKAEMIA (DRUG FOR RARE DISEASE IN EUROPE)
ROUTE (list)
INJECTION
ATC code
V04CG03
PK parameters
Tmax 0.3 HOUR
Cmax 38 NANOMOLAR (PMID12092744)
VD 59 LITER
Cl 210 LITER / HOUR
t1/2 0.18 HOUR
TARGET HISTAMINE RECEPTOR
PDB
1AVN (HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH THE HISTAMINE ACTIVATOR)
Ligand code = HSM (link to the list of PDB complexes)
Download experimental 3D coordinates of HSM with added hydrogens
Histamine H1 receptor UNIPROT P35367 HRH1
Formula:
C5H9N3
Calculated chemical properties:
MW 111.15
NB_atoms 8
XLogP -0.09
PSA 50.398
NB_HD 3
NB_HA 3
fsp3 0.40
Lipinski(0=no;1=yes) 1
NB_atoms 8
XLogP -0.09
PSA 50.398
NB_HD 3
NB_HA 3
fsp3 0.40
Lipinski(0=no;1=yes) 1
FDA
NDA 000734 (pdf not found) INN (HISTAMINE PHOSPHATE) HISTAMINE PHOSPHATE (LILLY) APPROVAL= AP YEAR= 1939 DISCONTINUED
NDA 000734 (pdf not found) INN (HISTAMINE PHOSPHATE) HISTAMINE PHOSPHATE (LILLY) APPROVAL= AP YEAR= 1939 DISCONTINUED