e-Drug3D

2183

LINERIXIBAT

INN
LINERIXIBAT

cas 1345982-69-5

CLASS

METABOLISM
TREATMENT OF CHOLESTATIC PRURITUS
AN ILEAL BILE ACID TRANSPORTER (IBAT) INHIBITOR

ROUTE (list)

ORAL

ATC code

A05AX08

PK parameters

F 0.05 PERCENT
Tmax 4.5 HOUR
PPB 73.7 PERCENT
t1/2 6.76 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET BILE ACID TRANSPORTER (IBAT)

Download SDF file

Pentanedioic acid, 3-[[[(3R,5R)-3-butyl-3-ethyl-2,3,4,5-tetrahydro-7-methoxy-1,1-dioxido-5-phenyl-1,4-benzothiazepin-8-yl]methyl]amino]-

Formula:
C28H38N2O7S

Calculated chemical properties:

MW 544.66
NB_atoms 38
XLogP 1.24
PSA 128.585
NB_HD 2
NB_HA 9
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
NDA 220295 (label) INN (LINERIXIBAT) LYNAVOY (INTERCEPT) APPROVAL= AP YEAR= 2026 NEWMOLECULARENTITY