e-Drug3D

2175

ZOLIFLODACIN

INN
ZOLIFLODACIN

cas 1620458-09-4

CLASS

ANTIINFECTIVES
SPIROPYRIMIDINETRIONE BACTERIAL TYPE II TOPOISOMERASE INHIBITOR
TREATMENT OF UNCOMPLICATED UROGENITAL GONORRHEA DUE TO NEISSERIA GONORRHOEAE

ROUTE (list)

ORAL

ATC code

PK parameters

Tmax 2.5 HOUR
VD 177 LITER
Cl 19.1 LITER / HOUR
PPB 83 PERCENT
t1/2 6.4 HOUR

Target

TARGET TOPOISOMERASE II

PDB
8BP2 (2.8A STRUCTURE OF ZOLIFLODACIN WITH S.AUREUS DNA GYRASE AND DNA)

Ligand code = R8U (link to the list of PDB complexes)

Download experimental 3D coordinates of R8U with added hydrogens

DrugCentral

Download SDF file

Spiro[isoxazolo[4,5-g][1,4]oxazino[4,3-a]quinoline-5(6H),5(2H)-pyrimidine]-2,4,6(1H,3H)-trione,11-fluoro-1,2,4,4a-tetrahydro-2,4-dimethyl-8-[(4S)-4-methyl-2-oxo-3-oxazolidinyl]-, (2R,4S,4aS)-

Formula:
C22H22FN5O7

Calculated chemical properties:

MW 487.45
NB_atoms 35
XLogP 1.20
PSA 139.628
NB_HD 2
NB_HA 12
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
NDA 219491 (label) INN (ZOLIFLODACIN) NUZOLVENCE (ENTASIS THERAP) APPROVAL= AP YEAR= 2025 NEWMOLECULARENTITY