e-Drug3D

2174

DIFAMILAST

INN
DIFAMILAST

cas 937782-05-3

CLASS

DERMATOLOGICALS
PHOSPHODIESTERASE 4 INHIBITOR
TREATMENT OF ATOPIC DERMATITIS

ROUTE (list)

TOPICAL

ATC code

PK parameters

PPB 99 PERCENT

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET PHOSPHODIESTERASE 4 (PDE4)

cAMP-specific 3,5-cyclic phosphodiesterase 4B UNIPROT Q07343 PDE4B_HUMAN

Download SDF file

Benzamide, N-[[2-[4-(difluoromethoxy)-3-(1-methylethoxy)phenyl]-4-oxazolyl]methyl]-2-ethoxy-

Formula:
C23H24F2N2O5

Calculated chemical properties:

MW 446.44
NB_atoms 32
XLogP 5.06
PSA 78.124
NB_HD 1
NB_HA 7
fsp3 0.30
Lipinski(0=no;1=yes) 0

FDA
NDA 219474 (label) INN (DIFAMILAST) ADQUEY (ACROTECH BIOPHARMA) APPROVAL= AP YEAR= 2026 NEWMOLECULARENTITY