e-Drug3D

2172

AFICAMTEN

INN
AFICAMTEN

cas 2364554-48-1

CLASS

CARDIOVASCULAR
A CARDIAC MYOSIN INHIBITOR
TREATMENT OF ADULTS WITH SYMPTOMATIC OBSTRUCTIVE HYPERTROPHIC CARDIOMYOPATHY (OHCM)

ROUTE (list)

ORAL

ATC code

PK parameters

Tmax 1.75 HOUR
VD 313 LITER
Cl 2.6 LITER / HOUR
PPB 90 PERCENT
t1/2 80 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET MYOSIN

PDB
9F6C (CARDIAC MYOSIN MOTOR DOMAIN IN THE PRE-POWERSTROKE STATE CO-CRYSTALLIZED WITH THE INHIBITOR AFICAMTEN)

Download experimental 3D coordinates of 6I6 with added hydrogens

Download SDF file

1H-Pyrazole-4-carboxamide, N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methyl-

Formula:
C18H19N5O2

Calculated chemical properties:

MW 337.38
NB_atoms 25
XLogP 2.45
PSA 79.005
NB_HD 1
NB_HA 7
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 219083 (label) INN (AFICAMTEN) MYQORZO (CYTOKINETICS) APPROVAL= AP YEAR= 2025 NEWMOLECULARENTITY