e-Drug3D

2169

NERANDOMILAST

INN
NERANDOMILAST

cas 1423719-30-5

CLASS

ANTINEOPLASTIC
IMMUNOMODULATING
INHIBITOR OF PHOSPHODIESTERASE 4
TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS (IPF)
ACTIVE R-ENANTIOMER AND INACTIVE S-ENANTIOMER

ROUTE (list)

ORAL

ATC code

L04AA61

PK parameters

F 73 PERCENT
Tmax 1.125 HOUR
VD 93 LITER
Cl 15.2 LITER / HOUR
PPB 77 PERCENT
t1/2 17 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET PHOSPHODIESTERASE 4

DrugCentral

Download SDF file

Cyclobutanemethanol, 1-[[(5R)-2-[4-(5-chloro-2-pyrimidinyl)-1-piperidinyl]-6,7-dihydro-5-oxidothieno[3,2-d]pyrimidin-4-yl]amino]-

Formula:
C20H25ClN6O2S

Calculated chemical properties:

MW 448.98
NB_atoms 30
XLogP 2.29
PSA 91.149
NB_HD 2
NB_HA 8
fsp3 0.60
Lipinski(0=no;1=yes) 1

FDA
NDA 218764 (label) INN (NERANDOMILAST) JASCAYD (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 2025 NEWMOLECULARENTITY
NDA 220449 (label) INN (NERANDOMILAST) JASCAYD (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 2025 NEWAPPLICATION