e-Drug3D

2144

ENSIFENTRINE

INN
ENSIFENTRINE

cas 1884461-72-6

CLASS

RESPIRATORY : PHOSPHODIESTERASE 3 (PDE3) INHIBITOR AND PHOSPHODIESTERASE 4 (PDE4) INHIBITOR INDICATED FOR THE MAINTENANCE TREATMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

ROUTE (list)

INHALATION

ATC code

R03BX02

PK parameters

Tmax 1 HOUR
VD 2700 LITER
PPB 90 PERCENT
t1/2 11.6 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET PHOSPHODIESTERASE 3 (PDE3)
PHOSPHODIESTERASE 4 (PDE4)

DrugCentral

Download SDF file

Urea, N-[2-[(2E)-6,7-dihydro-9,10-dimethoxy-4-oxo-2-[(2,4,6-trimethylphenyl)imino]-2H-pyrimido[6,1-a]isoquinolin-3(4H)-yl]ethyl]- (ACI)

Formula:
C26H31N5O4

Calculated chemical properties:

MW 477.56
NB_atoms 35
XLogP 2.72
PSA 104.9
NB_HD 3
NB_HA 9
fsp3 0.35
Lipinski(0=no;1=yes) 1

FDA
NDA 217389 (label) INN (ENSIFENTRINE) OHTUVAYRE (MSD) APPROVAL= AP YEAR= 2024 NEWMOLECULARENTITY