e-Drug3D

2141

ACORAMIDIS

INN
ACORAMIDIS

cas 1446711-81-4

CLASS

CARDIOVASCULAR
TRANSTHYRETIN STABILIZER
TREATMENT OF THE CARDIOMYOPATHY OF WILD-TYPE OR VARIANT TRANSTHYRETIN-MEDIATED AMYLOIDOSIS (ATTR-CM)
ACORAMIDIS BINDS TTR AT THYROXINE BINDING SITES AND SLOWS DISSOCIATION OF THE TTR TETRAMER

ROUTE (list)

ORAL

ATC code

C01EB25

PK parameters

Tmax 1 HOUR
Cmax 46.8 MICROMOLAR
VD 654 LITER
Cl 16 LITER / HOUR
PPB 96 PERCENT
t1/2 6 HOUR

Solubility

12 MICROGRAM PER MILLILITER

Target

TARGET TRANSTHYRETIN (TTR)

PDB
4HIQ (THE STRUCTURE OF V122I MUTANT TRANSTHYRETIN IN COMPLEX WITH AG10)

Ligand code = 16V (link to the list of PDB complexes)

Download experimental 3D coordinates of 16V with added hydrogens

DrugCentral

Download SDF file

Benzoic acid, 3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluoro- (ACI)

Formula:
C15H17FN2O3

Calculated chemical properties:

MW 291.30
NB_atoms 21
XLogP 1.54
PSA 73.478
NB_HD 1
NB_HA 5
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 216540 (label) INN (ACORAMIDIS HYDROCHLORIDE) ATTRUBY (BRIDGEBIO PHARMA) APPROVAL= AP YEAR= 2024 NEWMOLECULARENTITY