e-Drug3D

2090

VADADUSTAT

INN
VADADUSTAT

cas 1000025-07-9

CLASS

BLOOD
TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE (CKD)
HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE (HIF PH) INHIBITOR

ROUTE (list)

ORAL

ATC code

B03XA08

PK parameters

Tmax 2.5 HOUR
PPB 99.5 PERCENT
t1/2 9.2 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE (HIF PH)

PDB
5OPC (FACTOR INHIBITING HIF (FIH) IN COMPLEX WITH ZINC AND VADADUSTAT)

Download experimental 3D coordinates of A1Z with added hydrogens

Egl nine homolog 1 UNIPROT Q9GZT9 EGLN1

Egl nine homolog 2 UNIPROT Q96KS0 EGLN2

Download SDF file

Glycine, N-[[5-(3-chlorophenyl)-3-hydroxy-2-pyridinyl]carbonyl]- (ACI)

Formula:
C14H11ClN2O4

Calculated chemical properties:

MW 305.69
NB_atoms 21
XLogP 0.59
PSA 91.722
NB_HD 2
NB_HA 6
fsp3 0.07
Lipinski(0=no;1=yes) 1

FDA
NDA 215192 (label) INN (VADADUSTAT) VAFSEO (AKEBIA) APPROVAL= AP YEAR= 2024