e-Drug3D

2076

DAPRODUSTAT

DISCONTINUED

INN
DAPRODUSTAT

cas 960539-70-2

CLASS

BLOOD
HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE (HIF PH) INHIBITOR
PROLYL 4- HYDROXYLASES (PH)1, PH2 AND PH3 INHIBITOR
TREATMENT OF ANEMIA DUE TO CHRONIC KIDNEY DISEASE

ROUTE (list)

ORAL

ATC code

B03XA07

PK parameters

F 65 PERCENT
Tmax 2.5 HOUR
VD 14.3 LITER
Cl 15 LITER / HOUR
PPB 99 PERCENT
t1/2 2.5 HOUR

Solubility

POORLY SOLUBLE IN WATER

Target

TARGET HYPOXIA-INDUCIBLE FACTOR PROLYL HYDROXYLASE HIF-PH1
HIF-PH2
HIF-PH3

DrugCentral

Egl nine homolog 1 UNIPROT Q9GZT9 EGLN1

Egl nine homolog 2 UNIPROT Q96KS0 EGLN2

Download SDF file

Glycine, N-[(1,3-dicyclohexylhexahydro-2,4,6-trioxo-5-pyrimidinyl)carbonyl]- (ACI)

Formula:
C19H27N3O6

Calculated chemical properties:

MW 392.43
NB_atoms 28
XLogP -0.08
PSA 104.975
NB_HD 1
NB_HA 9
fsp3 0.74
Lipinski(0=no;1=yes) 1

FDA
NDA 216951 (label) INN (DAPRODUSTAT) JESDUVROQ (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2023 NEWMOLECULARENTITY DISCONTINUED