e-Drug3D

2075

OMAVELOXOLONE

INN
OMAVELOXOLONE

cas 1474034-05-3

CLASS

NERVOUS SYSTEM
TREATMENT OF FRIEDREICH’S ATAXIA
ACTIVATE THE NUCLEAR FACTOR (ERYTHROID-DERIVED 2)-LIKE 2 (NRF2) PATHWAY

ROUTE (list)

ORAL

ATC code

N07XX25

PK parameters

Tmax 10.5 HOUR
VD 7361 LITER
Cl 109 LITER / HOUR
PPB 97 PERCENT
t1/2 57 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

DrugCentral

Nuclear factor erythroid 2-related factor 2 UNIPROT Q16236

Download SDF file

Propanamide, N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoro- (ACI)

Formula:
C33H44F2N2O3

Calculated chemical properties:

MW 554.70
NB_atoms 40
XLogP 6.73
PSA 72.233
NB_HD 1
NB_HA 5
fsp3 0.76
Lipinski(0=no;1=yes) 0

FDA
NDA 216718 (label) INN (OMAVELOXOLONE) SKYCLARYS (BIOGEN US) APPROVAL= AP YEAR= 2023 NEWMOLECULARENTITY