e-Drug3D

2058

BEXAGLIFLOZIN

INN
BEXAGLIFLOZIN

cas 1118567-05-7

CLASS

METABOLISM
SODIUM-GLUCOSE CO-TRANSPORTER 2 (SGLT2) INHIBITOR
ANTIDIABETIC
REDUCES RENAL REABSORPTION OF FILTERED GLUCOSE
TREATMENT OF TYPE 2 DIABETES MELLITUS

ROUTE (list)

ORAL

ATC code

A10BK08

PK parameters

Tmax 3 HOUR
VD 262 LITER
Cl 19.1 LITER / HOUR
PPB 93 PERCENT
t1/2 12 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET SODIUM-GLUCOSE CO-TRANSPORTER 2
SGLT2

DrugCentral

sodium-glucose co-transporter 2 UNIPROT P31639

Download SDF file

D-Glucitol, 1,5-anhydro-1-C-[4-chloro-3-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]phenyl]-, (1S)- (ACI)

Formula:
C24H29ClO7

Calculated chemical properties:

MW 464.92
NB_atoms 32
XLogP 2.00
PSA 113.143
NB_HD 4
NB_HA 7
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 214373 (label) INN (BEXAGLIFLOZIN) BRENZAVVY (THERACOSBIO) APPROVAL= AP YEAR= 2023 NEWMOLECULARENTITY