e-Drug3D

2040

DIFELIKEFALIN

INN
DIFELIKEFALIN

cas 1024828-77-0

CLASS

VARIOUS
TREATMENT OF PRURITUS ASSOCIATED WITH KIDNEY DISEASE (CKD-AP)
KAPPA OPIOID RECEPTOR AGONIST
SYNTHETIC PEPTIDE

ROUTE (list)

INTRAVENOUS

ATC code

V03AX04

PK parameters

VD 15.5 LITER (65 KILOGRAM)
PPB 25 PERCENT
t1/2 27 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET KAPPA OPIOID RECEPTOR

Kappa-type opioid receptor UNIPROT P41145

Download SDF file

4-Piperidinecarboxylic acid, N1-(D-phenylalanyl-D-phenylalanyl-D-leucyl-D-lysyl)-4-amino- (ACI)

Formula:
C36H53N7O6

Calculated chemical properties:

MW 678.85
NB_atoms 49
XLogP -0.50
PSA 198.957
NB_HD 9
NB_HA 13
fsp3 0.53
Lipinski(0=no;1=yes) 0

FDA
NDA 214916 (label) INN (DIFELIKEFALIN ACETATE) KORSUVA (VIFOR INTL) APPROVAL= AP YEAR= 2021 NEWMOLECULARENTITY