e-Drug3D

2002

TIRBANIBULIN

INN
TIRBANIBULIN

cas 897016-82-9

CLASS

DERMATOLOGICALS
MICROTUBULE INHIBITOR
TREATMENT OF ACTINIC KERATOSIS OF THE FACE OR SCALP

ROUTE (list)

TOPICAL

ATC code

D06BX03

PK parameters

Tmax 7 HOUR
Cmax 0.78 NANOMOLAR
PPB 88 PERCENT

Target

TARGET TUBULIN

PDB
6KNZ (CRYSTAL STRUCTURE OF T2R-TTL-KXO1 COMPLEX)

Download experimental 3D coordinates of DN0 with added hydrogens

Tubulin beta chain UNIPROT P07437 TUBB

Download SDF file

2-Pyridineacetamide, 5-[4-[2-(4-morpholinyl)ethoxy]phenyl]-N-(phenylmethyl)-

Formula:
C26H29N3O3

Calculated chemical properties:

MW 431.52
NB_atoms 32
XLogP 3.32
PSA 61.567
NB_HD 1
NB_HA 6
fsp3 0.31
Lipinski(0=no;1=yes) 1

FDA
NDA 213189 (label) INN (TIRBANIBULIN) KLISYRI (ALMIRALL) APPROVAL= AP YEAR= 2020