e-Drug3D

1983

CAPMATINIB

INN
CAPMATINIB

cas 1029712-80-8

CLASS

ANTINEOPLASTIC
TREATMENT OF METASTATIC NON-SMALL CELL LUNG CANCER (NSCLC)
MET KINASE INHIBITOR

ROUTE (list)

ORAL

ATC code

L01EP01

PK parameters

F 70 PERCENT
Tmax 1.5 HOUR
VD 164 LITER
Cl 24 LITER / HOUR
PPB 96 PERCENT
t1/2 6.5 HOUR

Solubility

LOW SOLUBILITY IN WATER

Target

TARGET MET

Hepatocyte growth factor receptor UNIPROT P08581 MET

Download SDF file

Benzamide, 2-fluoro-N-methyl-4-[7-(6-quinolinylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-

Formula:
C23H17FN6O

Calculated chemical properties:

MW 412.43
NB_atoms 31
XLogP 3.43
PSA 74.354
NB_HD 1
NB_HA 7
fsp3 0.09
Lipinski(0=no;1=yes) 1

FDA
NDA 213591 (label) INN (CAPMATINIB HYDROCHLORIDE) TABRECTA (NOVARTIS PHARM) APPROVAL= AP YEAR= 2020 NEWMOLECULARENTITY