e-Drug3D

1978

ARTESUNATE

INN
ARTESUNATE

cas 88495-63-0

CLASS

ANTIINFECTIVES
ANTIMALARIAL
TREATMENT OF SEVERE MALARIA
SEMI-SYNTHETIC ARTEMISININ DERIVATIVE
RAPIDLY CONVERTED TO DHA BY BLOOD ESTERASES
ANTIPARASITIC

ROUTE (list)

INTRAVENOUS

ATC code

P01BE03
P01BF03
P01BF02
P01BF06
P01BF09
P01BF04

PK parameters

VD 68.5 LITER
Cl 180 LITER / HOUR
PPB 93 PERCENT
t1/2 0.3 HOUR

Target

PDB
6FGC (CRYSTAL STRUCTURE OF GEPHYRIN E DOMAIN IN COMPLEX WITH ARTESUNATE)

Ligand code = D95 (link to the list of PDB complexes)

Download experimental 3D coordinates of D95 with added hydrogens

DrugCentral

Unknown

Download SDF file

Butanedioic acid, 1-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl] ester

Formula:
C19H28O8

Calculated chemical properties:

MW 383.41
NB_atoms 27
XLogP 1.27
PSA 91.353
NB_HD 0
NB_HA 8
fsp3 0.89
Lipinski(0=no;1=yes) 1

FDA
NDA 213036 (label) INN (ARTESUNATE) ARTESUNATE (AMIVAS) APPROVAL= AP YEAR= 2020 NEWMOLECULARENTITY