e-Drug3D

1934

AMISULPRIDE

INN
AMISULPRIDE

cas 71675-85-9

CLASS

NERVOUS SYSTEM
DOPAMINE-2 (D2) ANTAGONIST FOR PREVENTION OF POSTOPERATIVE NAUSEA AND VOMITING (PONV)

ROUTE (list)

INTRAVENOUS

ATC code

N05AL05

PK parameters

Cmax 541.6 NANOMOLAR (5 MG)
VD 171 LITER
Cl 24.1 LITER / HOUR
PPB 27.5 PERCENT
t1/2 4.5 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET DOPAMINE-2 (D2) RECEPTOR
DOPAMINE-3 (D3) RECEPTOR

D(2) dopamine receptor UNIPROT P14416 DRD2

D(3) dopamine receptor UNIPROT P35462 DRD3

Download SDF file

Benzamide, 4-amino-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(ethylsulfonyl)-2-methoxy-

Formula:
C17H27N3O4S

Calculated chemical properties:

MW 369.49
NB_atoms 25
XLogP 1.29
PSA 92.171
NB_HD 3
NB_HA 7
fsp3 0.59
Lipinski(0=no;1=yes) 1

FDA
NDA 209510 (label) INN (AMISULPRIDE) BARHEMSYS (LXO IRELAND) APPROVAL= AP YEAR= 2020 NEWMOLECULARENTITY