e-Drug3D

1908

TAFENOQUINE

INN
TAFENOQUINE

cas 106635-80-7

CLASS

ANTIPARASITIC
ANTIMALARIAL
8-AMINOQUINOLINE
ACTIVE AGAINST ALL THE STAGES OF PLASMODIUM SPECIES
INHIBITS HEMATIN POLYMERIZATION AND INDUCES APOPTOTIC LIKE DEATH OF THE PARASITE

ROUTE (list)

ORAL

ATC code

P01BA07

PK parameters

Tmax 14 HOUR
VD 2470 LITER
Cl 4.2 LITER / HOUR
PPB 99.5 PERCENT
t1/2 396 HOUR

Target

PDB
7DDC (CRYSTAL STRUCTURE OF SARS-COV-2 MAIN PROTEASE IN COMPLEX WITH TAFENOQUINE)

Ligand code = H3F (link to the list of PDB complexes)

Download experimental 3D coordinates of H3F with added hydrogens

DrugCentral

Unknown

Download SDF file

1,4-Pentanediamine, N4-[2,6-dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-

Formula:
C24H28F3N3O3

Calculated chemical properties:

MW 463.49
NB_atoms 33
XLogP 5.91
PSA 75.215
NB_HD 3
NB_HA 6
fsp3 0.38
Lipinski(0=no;1=yes) 0

FDA
NDA 210795 (label) INN (TAFENOQUINE SUCCINATE) KRINTAFEL (GLAXOSMITHKLINE) APPROVAL= AP YEAR= 2018 NEWMOLECULARENTITY
NDA 210607 (label) INN (TAFENOQUINE SUCCINATE) ARAKODA (60 DEGREES PHARMS) APPROVAL= AP YEAR= 2018