e-Drug3D

1899

GLYCOPYRRONIUM

INN
GLYCOPYRRONIUM

cas 596-51-0

CLASS

METABOLISM
ANTICHOLINERGIC
COMPETITIVE INHIBITOR OF ACETYLCHOLINE RECEPTORS
TREATMENT OF PRIMARY AXILLARY HYPERHIDROSIS

ROUTE (list)

TOPICAL

ATC code

R03AL07
R03AL09
R03AL11
D11AA01
A03AB02
R03BB06
A03CA05
R03AL04
R03AL12

PK parameters

Tmax 1 HOUR
Cmax 0.25 NANOMOLAR
VD 27.3 LITER (65 KILOGRAM)

Target

TARGET MUSCARINIC ACETYLCHOLINE RECEPTOR

DrugCentral

Muscarinic acetylcholine receptor M1 UNIPROT P11229 CHRM1

Muscarinic acetylcholine receptor M2 UNIPROT P08172 CHRM2

Download SDF file

Pyrrolidinium, 3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethyl-

Formula:
C19H28NO3

Calculated chemical properties:

MW 318.42
NB_atoms 23
XLogP 2.46
PSA 41.261
NB_HD 1
NB_HA 3
fsp3 0.63
Lipinski(0=no;1=yes) 1

FDA
NDA 210361 (label) INN (GLYCOPYRRONIUM TOSYLATE) QBREXZA (JOURNEY) APPROVAL= AP YEAR= 2018
NDA 214448 (pdf not found) INN (GLYCOPYRRONIUM TOSYLATE) GLYCOPYRRONIUM TOSYLATE (PADAGIS US) APPROVAL= AP YEAR= 2026 DISCONTINUED